cholinesterase

General Information (Source: NCBI Gene,UniProt)

Text mining Term cholinesterase
UniProt ID CHLE_MOUSE
Name Butyrylcholine esterase
Pseudocholinesterase
Acylcholine acylhydrolase
Cholinesterase
Choline esterase II
Gene Names Bche
Taxonomy Mus musculus

General annotation

Function Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Subcellular location Secreted (By similarity).

Gene Ontology

GO:0007271 synaptic transmission, cholinergic BP
GO:0003990 acetylcholinesterase activity MF
GO:0019695 choline metabolic process BP
GO:0005615 extracellular space CC
GO:0004091 carboxylesterase activity MF
GO:0005641 nuclear envelope lumen CC
GO:0016020 membrane CC
GO:0005788 endoplasmic reticulum lumen CC

Sequence

>gi|124487350|ref|NP_033868.3| cholinesterase precursor [Mus musculus]
MQTQHTKVTQTHFLLWILLLCMPFGKSHTEEDFIITTKTGRVRGLSMPVLGGTVTAFLGIPYAQPPLGSL
RFKKPQPLNKWPDIHNATQYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNATVMV
WIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLAFPGNPDAPGNMGLFDQQLALQWVQRN
IAAFGGNPKSITIFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFTG
CSKENEMEMIKCLRSKDPQEILRNERFVLPSDSILSINFGPTVDGDFLTDMPHTLLQLGKVKKAQILVGV
NKDEGTAFLVYGAPGFSKDNDSLITRKEFQEGLNMYFPGVSRLGKEAVLFYYVDWLGEQSPEVYRDALDD
VIGDYNIICPALEFTKKFAELENNAFFYFFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLGRRVNYTRAEE
IFSRSIMKTWANFAKYGHPNGTQGNSTMWPVFTSTEQKYLTLNTEKSKIYSKLRAPQCQFWRLFFPKVLE
MTGDIDETEQEWKAGFHRWSNYMMDWQNQFNDYTSKKESCTAL

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000029367
UniGene Mm.250719
PDB
RefSeq NP_033868.3
Pfam PF08674
PF00135