IBAT

General Information (Source: NCBI Gene,UniProt)

Text mining Term IBAT
UniProt ID NTCP2_RAT
Name Na(+)-dependent ileal bile acid transporter
Ileal sodium/bile acid cotransporter
Ileal sodium-dependent bile acid transporter
Sodium/taurocholate-cotransporting polypeptide, ileal
Solute carrier family 10 member 2
Ileal Na(+)/bile acid cotransporter
ISBT
Apical sodium-dependent bile acid transporter
ASBT
IBAT
Gene Names Slc10a2
Synonyms:Ntcp2
Taxonomy Rattus norvegicus

General annotation

Function Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity).
Subcellular location Membrane; Multi-pass membrane protein.

Gene Ontology

GO:0016021 integral to membrane CC
GO:0008206 bile acid metabolic process BP
GO:0015711 organic anion transport BP
GO:0000502 proteasome complex CC
GO:0016324 apical plasma membrane CC
GO:0008508 bile acid MF
GO:0005634 nucleus CC

Sequence

>gi|8394281|ref|NP_058918.1| ileal sodium/bile acid cotransporter [Rattus norvegicus]
MDNSSVCSPNATFCEGDSCLVTESNFNAILSTVMSTVLTILLAMVMFSMGCNVEINKFLGHIKRPWGIFV
GFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGM
MPLCLFIYTKMWVDSGTIVIPYDSIGISLVALVIPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAV
VGGILYQSAWIIEPKLWIIGTIFPIAGYSLGFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSP
EDLNLVFTFPLIYTVFQLVFAAIILGMYVTYKKCHGKNDAEFLEKTDNDMDPMPSFQETNKGFQPDEK

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Database Cross Reference

Ensembl Gene ENSRNOT00000057310
UniGene Rn.85891
PDB
RefSeq NP_058918.1
Pfam PF01758