| Text mining Term | plasminogen |
|---|---|
| UniProt ID | PLMN_RAT |
| Name |
Activation peptide Angiostatin Plasmin heavy chain A Plasmin heavy chain A, short form Plasminogen Plasmin light chain B |
| Gene Names |
Plg
|
| Taxonomy | Rattus norvegicus |
| Function |
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity).
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo (By similarity). |
|---|---|
| Subcellular location |
Secreted (By similarity). Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity). |
| GO:0005792 | microsome | CC |
| GO:0048771 | tissue remodeling | BP |
| GO:0007596 | blood coagulation | BP |
| GO:0042730 | fibrinolysis | BP |
| GO:0051603 | proteolysis involved in cellular protein catabolic process | BP |
>gi|16758216|ref|NP_445943.1| plasminogen [Rattus norvegicus] MDHKEIILLFLLFLKPGQGDSLDGYVSTQGASLHSLTKKQLAAGSIADCLAKCEGETDFICRSFQYHSKE QQCVIMAENSKTSSIIRMRDVILFEKRVYLSECKTGIGKGYRGTMSKTKTGVTCQKWSDTSPHVPKYSPS THPSEGLEENYCRNPDNDEQGPWCYTTDPDQRYEYCNIPECEEECMYCSGEKYEGKISKTMSGLDCQSWD SQSPHAHGYIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPNKRWEYCDIPRCTTPPPPPGPTYQCLKGRG ENYRGTVSVTASGKTCQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPWCYTTDSQLRWEYCEIP SCGSSVSPDQSDSSVLPEQTPVVQECYQGNGKSYRGTSSTTNTGKKCQSWVSMTPHSHSKTPANFPDAGL EMNYCRNPDNDQRGPWCFTTDPSVRWEYCNLKRCSETGGGVAESAIVPQVPSAPGTSETDCMYGNGKEYR GKTAVTAAGTPCQEWAAQEPHSHRIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTMNPRKLYDYCNIPLC ASLSSFECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRFSGQHFCGGTLISPEWVLTAAHCLEKSS RPEFYKVILGAHEERILGSDVQQIAVTKLVLEPNDADIALLKLSRPATITDNVIPACLPSPNYVVADRTL CYITGWGETKGTPGAGRLKEAQLPVIENKVCNRAEYLNNRVKSTELCAGHLAGGIDSCQGDSGGPLVCFE KDKYILQGVTSWGLGCARPNKPGVYVRVSRYVNWIEREMRND |
| Ensembl Gene |
ENSRNOT00000023368 |
|---|---|
| UniGene |
Rn.20178 |
| PDB | |
| RefSeq |
NP_445943.1 |
| Pfam |
PF00051 PF00089 PF00024 |