| Text mining Term | bradykinin |
|---|---|
| UniProt ID | KNG1_RAT |
| Name |
Kininogen-1 heavy chain Kininogen-1 Bradykinin Kininogen-1 light chain |
| Gene Names |
Kng1
Synonyms:Kng |
| Taxonomy | Rattus norvegicus |
| Function |
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting. |
|---|---|
| Subcellular location |
Secreted, extracellular space. |
| GO:0004869 | cysteine-type endopeptidase inhibitor activity | MF |
| GO:0002020 | protease binding | MF |
| GO:0048146 | positive regulation of fibroblast proliferation | BP |
| GO:0001938 | positive regulation of endothelial cell proliferation | BP |
| GO:0045861 | negative regulation of proteolysis | BP |
| GO:0005792 | microsome | CC |
| GO:0042130 | negative regulation of T cell proliferation | BP |
| GO:0005615 | extracellular space | CC |
| GO:0043407 | negative regulation of MAP kinase activity | BP |
| GO:0042311 | vasodilation | BP |
| GO:0043410 | positive regulation of MAPKKK cascade | BP |
| GO:0007596 | blood coagulation | BP |
| GO:0006954 | inflammatory response | BP |
| GO:0043204 | perikaryon | CC |
>gi|7549773|ref|NP_036873.1| kininogen-1 isoform 1 precursor [Rattus norvegicus] MKLITILLLCSRLLPSLAQEEDAQEMDCNDESLFQAVDTALKKYNAGLKSGNQFVLYQVTEGTKKDGSKT FYSFKYQIKEGNCSVQSGFAWQDCDFKDAEEAATGECTATLEKRRNNKFSIATQICNITPGKGPIVTNEY HCLGCMHPISVDSPELGPVLKHAVEHFNNNTKHTHLFALGEVKSADRQVVAGMNYQIIYSIVQTNCSKED FPSLHEDCVPLPSGDDGECKGNAFVDIHKTIAGFSDSCEFYPGDDLFELLPEDCPGCPRNIPVDSPELKE ALGHSIAQLNAENNHTFYFKIDTVKKATSQVVAGTKYVIEFIARETKCSKESNAELTADCETKRLGQSLN CNANVYMRPWENKVVPTVKCKVLDMTSVIRRPPGFSPFRAPRVKKPKESTTVSPSYIARVQEERDPGNEQ GPIHGHGWLHAKQIKNKNHQGHKHGHGIGHGHQKPHGLGHGHQLKLDDLKQQREDGYDHRHPVGHGHGQR HGHGHGHGHGRDKHTNKDKNNVKHTDQRRAPLTSSSEDNTTSTQIQGRTEGFTLNPPLAQPAVISRGFQD SGFTEGVIATTSPYDTETHDDLIPDIHVQPDSLSFKLISDFPEATSHKCPGRPWKPVSRKDPTIETTEFS DFDLLDALS |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.128333 Rn.44576 |
| PDB | |
| RefSeq |
NP_036873.1 |
| Pfam |
PF00031 |