plasminogen

General Information (Source: NCBI Gene,UniProt)

Text mining Term	plasminogen
UniProt ID	PLMN_MOUSE
Name	Plasmin light chain B Plasmin heavy chain A, short form Activation peptide Plasminogen Angiostatin Plasmin heavy chain A
Gene Names	Plg
Taxonomy	Mus musculus

General annotation

Function	Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
Subcellular location	Secreted (By similarity). Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity).

Function

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.

Subcellular location

Secreted (By similarity). Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity).

Gene Ontology

GO:0042730	fibrinolysis	BP
GO:0016525	negative regulation of angiogenesis	BP
GO:0060707	trophoblast giant cell differentiation	BP
GO:0060716	labyrinthine layer blood vessel development	BP
GO:0048771	tissue remodeling	BP
GO:0071674	mononuclear cell migration	BP
GO:0042246	tissue regeneration	BP
GO:0006917	induction of apoptosis	BP
GO:0007596	blood coagulation	BP
GO:0005615	extracellular space	CC
GO:0006915	apoptotic process	BP
GO:0046716	muscle cell homeostasis	BP
GO:0045445	myoblast differentiation	BP

Sequence

>gi|257471003|ref|NP_032903.3| plasminogen precursor [Mus musculus]
MDHKEVILLFLLLLKPGQGDSLDGYISTQGASLFSLTKKQLAAGGVSDCLAKCEGETDFVCRSFQYHSKE
QQCVIMAENSKTSSIIRMRDVILFEKRVYLSECKTGIGNGYRGTMSRTKSGVACQKWGATFPHVPNYSPS
THPNEGLEENYCRNPDNDEQGPWCYTTDPDKRYDYCNIPECEEECMYCSGEKYEGKISKTMSGLDCQAWD
SQSPHAHGYIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPTKRWEYCDIPRCTTPPPPPSPTYQCLKGRG
ENYRGTVSVTVSGKTCQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPWCYTTDSQLRWEYCEIP
SCESSASPDQSDSSVPPEEQTPVVQECYQSDGQSYRGTSSTTITGKKCQSWAAMFPHRHSKTPENFPDAG
LEMNYCRNPDGDKGPWCYTTDPSVRWEYCNLKRCSETGGSVVELPTVSQEPSGPSDSETDCMYGNGKDYR
GKTAVTAAGTPCQGWAAQEPHRHSIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTTNPRKLYDYCDIPLC
ASASSFECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRFTGQHFCGGTLIAPEWVLTAAHCLEKSS
RPEFYKVILGAHEEYIRGLDVQEISVAKLILEPNNRDIALLKLSRPATITDKVIPACLPSPNYMVADRTI
CYITGWGETQGTFGAGRLKEAQLPVIENKVCNRVEYLNNRVKSTELCAGQLAGGVDSCQGDSGGPLVCFE
KDKYILQGVTSWGLGCARPNKPGVYVRVSRFVDWIEREMRNN

Database Cross Reference

Ensembl Gene	ENSMUST00000014578
UniGene	Mm.971
PDB
RefSeq	NP_032903.3
Pfam	PF00051 PF00024 PF00089

PTID

plasminogen

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference