Nociceptin

General Information (Source: NCBI Gene,UniProt)

Text mining Term Nociceptin
UniProt ID PNOC_RAT
Name ORL1 receptor agonist
Orphanin FQ
PPNOC
Prepronociceptin
Neuropeptide 2
Nociceptin
Neuropeptide 1
Gene Names Pnoc
Taxonomy Rattus norvegicus

General annotation

Function Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
Subcellular location Secreted.

Gene Ontology

GO:0005576 extracellular region CC
GO:0001515 opioid peptide activity MF
GO:0007268 synaptic transmission BP
GO:0007218 neuropeptide signaling pathway BP

Sequence

>gi|6981378|ref|NP_037139.1| prepronociceptin precursor [Rattus norvegicus]
MKILFCDVLLLSLLSSVFSSCPEDCLTCQERLHPAPGSFNLKLCILQCEEKVFPRPLWTLCTKAMASDSE
QLSPADPELTSAALYQSKASEMQHLKRMPRVRSVVQARDAEPEADAEPVADEADEVEQKQLQKRFGGFTG
ARKSARKLANQKRFSEFMRQYLVLSMQSSQRRRTLHQNGNV

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.87935
PDB
RefSeq NP_037139.1
Pfam PF01160