NK 2 receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term NK 2 receptor
UniProt ID NK2R_MOUSE
Name Substance-K receptor
NK-2R
NK-2 receptor
Tachykinin receptor 2
Neurokinin A receptor
SKR
Gene Names Tacr2
Synonyms:Tac2r
Taxonomy Mus musculus

General annotation

Function This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0005886 plasma membrane CC
GO:0004995 tachykinin receptor activity MF
GO:0016021 integral to membrane CC

Sequence

>gi|258613887|ref|NP_033340.3| substance-K receptor [Mus musculus]
MGAHASVTDTNILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNY
FIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAADRYMAIVHPFQ
PRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPL
VVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIY
YRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWGTPTEEDRLELTHTPSISRRVNR
CHTKETLFMTGDMTHSEATNGQVGGPQDGEPAGP

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Database Cross Reference

Ensembl Gene ENSMUST00000020278
UniGene Mm.8054
PDB
RefSeq NP_033340.3
Pfam PF00001