Mu opioid receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term Mu opioid receptor
UniProt ID OPRM_RAT
Name MOR-1
Mu-type opioid receptor
M-OR-1
Opioid receptor B
Gene Names Oprm1
Taxonomy Rattus norvegicus

General annotation

Function Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0045121 membrane raft CC
GO:0032100 positive regulation of appetite BP
GO:0060079 regulation of excitatory postsynaptic membrane potential BP
GO:0031635 inhibition of adenylate cyclase activity by opioid receptor signaling pathway BP
GO:0032839 dendrite cytoplasm CC
GO:0070848 response to growth factor stimulus BP
GO:0005515 protein binding MF
GO:0051930 regulation of sensory perception of pain BP
GO:0005887 integral to plasma membrane CC
GO:0005925 focal adhesion CC
GO:0032590 dendrite membrane CC
GO:0005624 membrane fraction CC
GO:0042060 wound healing BP
GO:0043204 perikaryon CC
GO:0032094 response to food BP
GO:0042220 response to cocaine BP
GO:0032496 response to lipopolysaccharide BP
GO:0043278 response to morphine BP
GO:0002438 acute inflammatory response to antigenic stimulus BP

Sequence

>gi|145553980|ref|NP_001033688.2| mu-type opioid receptor isoform 1B2 [Rattus norvegicus]
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAIT
IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILC
KIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY
RQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITR
MVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREF
CIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQEPQSVET

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000051837
ENSRNOT00000064376
ENSRNOT00000044912
ENSRNOT00000066989
ENSRNOT00000060637
UniGene Rn.10118
PDB
RefSeq NP_037203.1
NP_001033689.1
NP_001033688.2
NP_001033690.1
NP_001033686.1
Pfam PF00001