5 HT 1B

General Information (Source: NCBI Gene,UniProt)

Text mining Term 5 HT 1B
UniProt ID 5HT1B_RAT
Name 5-HT1B
5-hydroxytryptamine receptor 1B
Serotonin receptor 1B
5-HT-1B
Gene Names Htr1b
Synonyms:5ht1b
Taxonomy Rattus norvegicus

General annotation

Function This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0004993 serotonin receptor activity MF
GO:0042220 response to cocaine BP
GO:0045471 response to ethanol BP
GO:0042756 drinking behavior BP
GO:0016021 integral to membrane CC
GO:0051385 response to mineralocorticoid stimulus BP
GO:0032229 negative regulation of synaptic transmission, GABAergic BP
GO:0051967 negative regulation of synaptic transmission, glutamatergic BP
GO:0014059 regulation of dopamine secretion BP
GO:0008144 drug binding MF
GO:0005886 plasma membrane CC
GO:0051378 serotonin binding MF
GO:0007268 synaptic transmission BP

Sequence

>gi|11560016|ref|NP_071561.1| 5-hydroxytryptamine receptor 1B [Rattus norvegicus]
MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATV
YRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIA
LDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTV
GAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSP
VYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFF
NWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000017411
UniGene Rn.138109
PDB
RefSeq NP_071561.1
Pfam PF00001