cytochrome P450 2E1

General Information (Source: NCBI Gene,UniProt)

Text mining Term cytochrome P450 2E1
UniProt ID CP2E1_RAT
Name 4-nitrophenol 2-hydroxylase
Cytochrome P450 2E1
Cytochrome P450RLM6
Cytochrome P450-J
CYPIIE1
Gene Names Cyp2e1
Taxonomy Rattus norvegicus

General annotation

Function Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites (By similarity).
Subcellular location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Gene Ontology

GO:0005792 microsome CC
GO:0000139 Golgi membrane CC
GO:0005739 mitochondrion CC
GO:0010243 response to organic nitrogen BP
GO:0031227 intrinsic to endoplasmic reticulum membrane CC
GO:0009055 electron carrier activity MF
GO:0010193 response to ozone BP
GO:0045471 response to ethanol BP
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen MF
GO:0006641 triglyceride metabolic process BP
GO:0010181 FMN binding MF
GO:0020037 heme binding MF
GO:0006805 xenobiotic metabolic process BP
GO:0042493 response to drug BP
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen MF

Sequence

>gi|13928734|ref|NP_113731.1| cytochrome P450 2E1 [Rattus norvegicus]
MAVLGITIALLVWVATLLVISIWKKIYNSWNLPPGPFPLPILGNIFQLDLKDIPKSFTKLAKRFGPVFTL
HLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGK
QGNEARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKKCLRLMSLFNENFYLL
STPWIQLYNNFADYLRYLPGSHRKIMKNVSEIKQYTLEKAKEHLQSLDINCARDVTDCLLIEMEKEKHSQ
EPMYTMENVSVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYM
DAVVHEIQRFINLVPSNLPHEATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGK
FKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQFKLCVI
PRS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000016883
UniGene Rn.1372
PDB
RefSeq NP_113731.1
Pfam PF00067