adenylate cyclase

General Information (Source: NCBI Gene,UniProt)

Text mining Term adenylate cyclase
UniProt ID CYA1_DROME
Name Protein rutabaga
ATP pyrophosphate-lyase
Ca(2+)/calmodulin-responsive adenylate cyclase
Gene Names rut
Taxonomy Drosophila melanogaster

General annotation

Function This is a membrane-bound, calmodulin-sensitive adenylyl cyclase. Inactivation of this cyclase leads to a learning and memory defect.
Subcellular location Membrane; Multi-pass membrane protein.

Gene Ontology

GO:0009408 response to heat BP
GO:0007619 courtship behavior BP
GO:0008340 determination of adult lifespan BP
GO:0005524 ATP binding MF
GO:0001661 conditioned taste aversion BP
GO:0016021 integral to membrane CC
GO:0006979 response to oxidative stress BP
GO:0005516 calmodulin binding MF
GO:0007625 grooming behavior BP
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity MF
GO:0007274 neuromuscular synaptic transmission BP
GO:0007591 molting cycle, chitin-based cuticle BP
GO:0048675 axon extension BP
GO:0019933 cAMP-mediated signaling BP
GO:0007186 G-protein coupled receptor signaling pathway BP
GO:0030431 sleep BP
GO:0007614 short-term memory BP
GO:0008355 olfactory learning BP
GO:0046872 metal ion binding MF
GO:0048149 behavioral response to ethanol BP

Sequence

>gi|68067621|sp|P32870.2|CYA1_DROME RecName: Full=Ca(2+)/calmodulin-responsive adenylate cyclase; AltName: Full=ATP pyrophosphate-lyase; AltName: Full=Protein rutabaga
MDHAVKATRGRPLNTLRFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIF
NAIVCGLFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQIVFVV
FLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERA
QRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFAD
IVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDM
IDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSL
SGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHT
IKFSEPVPFSNIATGSFPSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKI
LHATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNK
SQSKVADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDF
DLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSLRM
AITIFTVILIYSVGQVNVFTCVSDHPCSGNGTTSFQNDSHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIF
KSLLVLGMGTIYGLFIELSHQNIFECYDNRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQ
LQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMD
GSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIE
YVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQE
VVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSLNGEVRNAMSLPQSLHAPDYYMKVSQFPENRV
NTDTYSKKENGHLYAGNGVEEQQLLLQHQHKQHDPLPLPAPPPPVHHHLHQQQQQRLNSKLQKQPIFMAN
GGLPNIRENGNGHNGEHQQQQQQQQQHQQQQQQQQQHGGFMVATTTPPAAVAVPLQPQHHQLQFQHPHQH
PLPSAVSVPVQHQILLHHQLQLQHQPVPSVMLREFNIIENPTSGGRHQQMEQLPPHHGSLDLSGMGMGVG
AGVLGSDCFMMPRRDRERTYVPPLNQHGHHPPHHLHSNLNLNQSQHPPSFTSLGYGQCRESEPLLHASSV
APVAKIMPMQHAPKYEPPRYTSPHTMLSQQHQQQQQQQHQHQQPQSQSAQDQQTHPAQDPHPLQRQYAMY
SQQPQLPPKPVLRTYMKPLPKLPTDLEESRDMSSTDDLSSRPHSPSMSSSDESYSKTTEGEGEGDEDSPR
MVNGGHLHHRNGYHLPAGGLVNPLQWLYPCDIQVDPTSPVVDMAHLHDFELSSTTESQGHHTNSNTTSNT
QHKGDSCNSFDFQKAAVGTAAGAAIATKSPFERELQRLLNESSRARCLATATTTAGAISTTDQTASNGSR
ELSYSLSNGKLSSANGHGVGGSGSGSGSGSGSGSAVGNGSGGSGSSNGNLSGGSGSNSNSGNNNSSHHKT
EQQQNMDHEHLAGGKLLGSNSFMIAKHPVGLEAIKEITRNKNPSESSQMQTSDTESCEILHENRNQMHVL
AMLEMHTAKELNGSHAHHGQHHQQPQRTHRQRPRSKELQYSHESLDGLDGAVQSQSQQRHQRYHHHHHHQ
QRQQQQQRYNHVQEQEERDDTEDNLADEEFEDDEVGRDVRQKRLQKSELNHKRSEVATEAGNHHDDEVEE
EDDDDDEEEDHRNGGREAAPLTNGSMRGLEANVINDELKYGATHLNHQSMDSNPLESQSEWSDDDCREEA
TGGAESTGYITDEPGLENISLLNEAGLTDAEGALSDVNSLYNAPDVDDTSVSSRASSRLLSLDSLSGLYD
CDLDSKHELAIVNASHKISSKFGQPLSPAQQQHQQQQQQQQQQQQQHHQQQLQQNPQHTQAQSHLAPVQF
QSAEELRE

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.2613
PDB
RefSeq NP_511156.2
Pfam PF00211
PF06327