NMDA receptor (protein family or complex)

General Information (Source: NCBI Gene,UniProt)

Text mining Term NMDA receptor (protein family or complex)
UniProt ID NMDA1_DROME
Name DNMDAR-I
dNR1
Glutamate [NMDA] receptor subunit 1
Gene Names Nmdar1
Taxonomy Drosophila melanogaster

General annotation

Function NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation.
Subcellular location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Gene Ontology

GO:0030288 outer membrane-bounded periplasmic space CC
GO:0004970 ionotropic glutamate receptor activity MF
GO:0030054 cell junction CC
GO:0042391 regulation of membrane potential BP
GO:0045211 postsynaptic membrane CC
GO:0042331 phototaxis BP
GO:0055074 calcium ion homeostasis BP
GO:0005234 extracellular-glutamate-gated ion channel activity MF
GO:0008355 olfactory learning BP
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex CC
GO:0014069 postsynaptic density CC
GO:0007268 synaptic transmission BP
GO:0035235 ionotropic glutamate receptor signaling pathway BP
GO:0007616 long-term memory BP

Sequence

>gi|7296737|gb|AAF52016.1| NMDA receptor 1 [Drosophila melanogaster]
MAMAEFVFCRPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPR
KVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAA
FSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATV
ELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPD
GVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGET
GQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHL
RLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSP
DGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPS
RSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLL
NSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVK
GSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGR
SGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVFILVG
VGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHAPGTI
SLAVDKRRYPRLGQRLGPERAWPGDAADVLRIRRPYELGNPGQSPKVMAANQPGMPMPMLGKTRPQQSVL
PPRYSPGYTSDVSHLVV

Options for BLAST

Database:

Set subsequence:(optional):
From: To:

Optional parameters:
Expect:
Descriptions:

Database Cross Reference

Ensembl Gene
UniGene Dm.3670
PDB
RefSeq NP_730940.1
Pfam PF00060
PF00497
PF10562
PF01094