phosphodiesterase

General Information (Source: NCBI Gene,UniProt)

Text mining Term phosphodiesterase
UniProt ID PDE6_DROSI
Name cGMP-specific 3',5'-cyclic phosphodiesterase
Gene Names Pde6
Taxonomy Drosophila simulans

General annotation

Function Has a role regulating cGMP transport in Malpighian tubule principal cells (By similarity).
Subcellular location Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity).

Gene Ontology

GO:0007165 signal transduction BP
GO:0046068 cGMP metabolic process BP
GO:0005886 plasma membrane CC
GO:0046872 metal ion binding MF
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity MF

Sequence

>gi|223635604|sp|B4QZU1.1|PDE6_DROSI RecName: Full=cGMP-specific 3',5'-cyclic phosphodiesterase; Flags: Precursor
MHGPVSRSSSSSNMTDVSSPAGGAASPVEMTTSSSSAATTSASSSKPLTNGANKTTISTVAGGVAPGAVP
GPGSGAIPASSSSGNQVKLEHHHRQSNNNRPAATNRSSETKLRSPAGESDGASRLMTPAGSSSSPSQSPS
QTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKR
PSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKI
LVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQM
INIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFC
GIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEAS
HLEKIIEKPNQQATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATT
GQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFA
IFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDD
DTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTD
LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYR
SVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAK
LVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENR
RNWQDLAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGS
RLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKTSLKLLESHVSEDMDDKSPTSPSQPQASGSMGRMSASS
STSSTGGQMVDKSKKRSKLCALL

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq XP_002103436.1
Pfam PF01590
PF00233