NADPH cytochrome P450 reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term NADPH cytochrome P450 reductase
UniProt ID NCPR_DROME
Name CPR
P450R
NADPH--cytochrome P450 reductase
Gene Names Cpr
Taxonomy Drosophila melanogaster

General annotation

Function This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5. May function to clear the olfactory organ (antennae) from accumulating chemicals.
Subcellular location Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Note=Anchored to the ER membrane by its N-terminal hydrophobic region (By similarity).

Gene Ontology

GO:0003958 NADPH-hemoprotein reductase activity MF
GO:0005506 iron ion binding MF
GO:0010181 FMN binding MF
GO:0005789 endoplasmic reticulum membrane CC

Sequence

>gi|12643739|sp|Q27597.2|NCPR_DROME RecName: Full=NADPH--cytochrome P450 reductase; Short=CPR; Short=P450R
MASEQTIDGAAAIPSGGGDEPFLGLLDVALLAVLIGGAAFYFLRSRKKEEEPTRSYSIQPTTVCTTSASD
NSFIKKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVFC
LATYGEGDPTDNAMEFYEWITSGDVDLSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLG
DDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLIRQYRLLEQPDVQPDRIYTGEIARLHSIQNQRPPF
DAKNPFLAPIKVNRELHKGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDKSLVEKLGQLCNADLDTVF
SLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEKY
QSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGRIN
KGVATTYLKNKQPQGSEEVKVPVFIRKSQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVG
ESILYFGCRKRSEDYIYESELEEWVKKGTLNLKAAFSRDQGKKVYVQHLLEQDADLIWNVIGENKGHFYI
CGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVWS

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Database Cross Reference

Ensembl Gene
UniGene Dm.6997
PDB
RefSeq NP_477158.1
Pfam PF00258
PF00175
PF00667