CREB

General Information (Source: NCBI Gene,UniProt)

Text mining Term CREB
UniProt ID CREBA_DROME
Name Cyclic AMP response element-binding protein A
Box B-binding factor 2
BBF-2
cAMP response element-binding protein A
dCREB-A
Gene Names CrebA
Synonyms:Bbbf2
Taxonomy Drosophila melanogaster

General annotation

Function Transcriptional activator. Binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes. BBF-2 may play a role in fat body gene expression. It binds the consensus sequence 5'-T[AC]NACGTAN[TG]C-3'.
Subcellular location Nucleus.

Gene Ontology

GO:0046983 protein dimerization activity MF
GO:0006357 regulation of transcription from RNA polymerase II promoter BP
GO:0006351 transcription, DNA-dependent BP
GO:0001158 enhancer sequence-specific DNA binding MF
GO:0035293 chitin-based larval cuticle pattern formation BP
GO:0045893 positive regulation of transcription, DNA-dependent BP
GO:0009953 dorsal/ventral pattern formation BP
GO:0005634 nucleus CC
GO:0007435 salivary gland morphogenesis BP
GO:0003700 sequence-specific DNA binding transcription factor activity MF

Sequence

>gi|45553137|ref|NP_996096.1| Cyclic-AMP response element binding protein A, isoform B [Drosophila melanogaster]
MEFYDGDLKDIWDSDLDPESLKISPDHDMHDWLFDRDVKDPTVILNDKLISDALLNGTQPIKTEHSYSLS
SDVDSLPDSPKSLQAKIEDMDDECFPAISPKTATNGRVTIDPKYLTFHVPPTHATPISRLSSNPALNTSV
ADLTRSSGLQSLQAHQPHHGSGSSHVVVANLEHFQLPQHLYDNDCSSSVSSLRDGSMSPDICSDIEIDES
AIKDEPMSPDSSCPASPTSQASSSQHQLSLNLAHLQSEMLFEPKHCGLLLTASSNSNNSLIKSQQRQQQI
LGQDNLLMAKMEIKSEKQSTSNSSDKSHAHGYGIPLTPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISV
ANPAGGESSVRVSRTAASITRSSSGSASASGSSTSSTVTTTRQPIHTPLISSQPKGSTGTLLLTEEEKRT
LLAEGYPIPQKLPLTKAEEKSLKKIRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGL
EETNANLLSQLHKLQALVSKHNVKKS

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.6979
PDB
RefSeq NP_996096.1
NP_524087.3
Pfam PF00170