lysophospholipase

General Information (Source: NCBI Gene,UniProt)

Text mining Term lysophospholipase
UniProt ID NTE1_SCHPO
Name Lysophospholipase NTE1
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene Names nte1
Taxonomy Schizosaccharomyces pombe 972h-

General annotation

Function Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0004091 carboxylesterase activity MF
GO:0034638 phosphatidylcholine catabolic process BP
GO:0005789 endoplasmic reticulum membrane CC
GO:0016021 integral to membrane CC
GO:0004622 lysophospholipase activity MF

Sequence

>gi|19075586|ref|NP_588086.1| lysophospholipase [Schizosaccharomyces pombe 972h-]
MDITDRILQNRIVSKVIFFVLRSVTLSLVSVTRFSLFLLSFATITVPKWAYKIVTYSLTIQFNFKSLLFL
FFVSICVVILVVRYRYLNKYARLPHEAPIKEAKLGPDTNIRPSEPRIGFQNYLDEFLSAISIFGYLEKPV
FVELARHIRTQRVAEGNTIYLGEQSSFILVVDGCFQVFTAPEKDSAEVVEEAGQPEYRLLTEVSNGAPLS
SFFTVLELFTELIPEATSKENPFKSTTSSLRPGSSTTTEAGANNASKPHMPQPKKARIIAKAKIDTTIAV
IPANAFHHLVHKFPNSSAQIVQVILTRFQRVTFSTGYEYLGLSDAIFSIEKNFNSLTAYELPNYIRSDII
DDFKKEAMSEHLSQASNESFIVLRSKGAQSRLSNQYFSKAFDKEHGNFVSDIDRSTANAGDLLSSTNPHS
TLLSTSVGPLRKFPLNRSYSREVGDYDISASFRDGLLQCIFKSLGVFNYELKEDNDDLCTENDSSEGDSD
SLKKVDFLGQIAMMSATDREEVKSSIVVSTKKSTILEFAKEIEIIFYKKGTTIVRQGDHADGLYYIIDGF
LDATCPSKLTFSTSYDTDLGMHSFMIKPGGIVNYQACVSNYRSFINVTARSDVLVGFLPRSCLERIIDQE
PLISLTIAKRLISLVPSLLLKLDFAVGWIHLNPDQVVYEKNDPSDCVYVVLNGRLRSIEDERGSARTQVD
YFNEYGKGDSVGELEMLLNNRRSSTLFAIRDSELAKIPETLFNALSLSHPAVGLQLSKIIANRMNLLLNN
KSMDGMQHQPHEKHSIRTLAIVPSSSTGLLILFSQKLTSVLSVMGKSVKVLRQSSVLEHLGKHAFSRMGR
FKLSSYLSDLEDKYDILIYVADSGVGSAWLQTCIRQADCIYILAEADQNPNIGEYEQHLIAMKSTARKEL
VLLHPERFCPSGLTRLWLKERPWVYAHHHVQLRIGLDNEISQNNEAKVFLNIIRAKVQNLHYGFRKYIDW
KHLHPVYQANRAQDSDFARLARRICGKAIALVLGGGGARGISQIGILYALEEAGIPFDIIGGTSIGAFNG
GLYAWEADLVPMFGRAKKFCGRMANLWRFVLDVTYPQAAYTTGHEFNRGIWKTFGEIHIEDFWLPFYANT
TNITHSRMDIHSSGYAWRYIRASMSLAGLVPPMLSDSGDMLLDGGYMDNLTVSHMQSLGASSIFAIDVGS
EDSREPMHYGDTVSGVWALISRWIPFIPKTSFPSLAEIQSRLTYVTSVATGEKVKSMPGCFYMRPPVKDF
PTLEFGSFEKIYNVGYNYGKEYVEKLKTSHKLDDILSPRDTSKRHPKFLSSRRNSL

Options for BLAST

Database:

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq NP_588086.1
Pfam PF00027
PF01734