cyclin dependent protein kinase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	cyclin dependent protein kinase
UniProt ID	SSN3_CRYNJ
Name	Cyclin-dependent kinase 8 Serine/threonine-protein kinase SSN3
Gene Names	SSN3 Synonyms:CDK8
Taxonomy	Cryptococcus neoformans var. neoformans JEC21

General annotation

Function	Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II- dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
Subcellular location	Nucleus (Probable).

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II- dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).

Subcellular location

Nucleus (Probable).

Gene Ontology

GO:0005524	ATP binding	MF
GO:0006355	regulation of transcription, DNA-dependent	BP
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	MF
GO:0006351	transcription, DNA-dependent	BP
GO:0004693	cyclin-dependent protein kinase activity	MF
GO:0005634	nucleus	CC
GO:0046872	metal ion binding	MF

Sequence

>gi|58262012|ref|XP_568416.1| cyclin-dependent protein kinase [Cryptococcus neoformans var. neoformans JEC21]
MATIPGGGTIMDPMHLYRARRDKERRGVLKTYKILGFISSGTYGRVYKAVLLPPPKTASAKSALPSSTRA
ALSLPKDKLPSPSFTEDSDPLNNPEMCMRPGDRPAKRGDVFAIKKFKPDKEGDVLTYAGISQSGAREIML
NRELHHRNLVSLREVILEDKSIYMVFEYAEHDFLQIIHYHSQTARASIPPSTLRRLLHQLLCGVHFLHSN
FVLHRDLKPANILVTSQGVVKIGDLGLARLWHKPLAQQGLYGGDKVVVTIWYRAPELILGAKHYTAAVDI
WAVGCIYAELLSLRPIFKGDEAKMDGKKSLPFQRDQMGKICEVLGPVKPEQWPGIVHMPEYRTYQATGPY
PHSNPLAPWYHARSNSSEGYDILVKMFEWDPARRITARDALRHPWFQEEGGVDTKSVFEGSSITYPTRRV
THEDNGDAKMGSLPQSMAGGRLPSSSNFRPASGNIVQPAARKKARI

Database Cross Reference

Ensembl Gene
UniGene	Fne.1167
PDB
RefSeq	XP_568416.1
Pfam	PF00069

PTID

cyclin dependent protein kinase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference