fibrillarin

General Information (Source: NCBI Gene,UniProt)

Text mining Term fibrillarin
UniProt ID FBRL_SCHPO
Name rRNA 2'-O-methyltransferase fibrillarin
Gene Names fib1
Synonyms:fib
Taxonomy Schizosaccharomyces pombe 972h-

General annotation

Function Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).
Subcellular location Nucleus, nucleolus. Note=Fibrillar region of the nucleolus.

Gene Ontology

GO:0008033 tRNA processing BP
GO:0005730 nucleolus CC
GO:0000494 box C/D snoRNA 3'-end processing BP
GO:0032040 small-subunit processome CC
GO:0031167 rRNA methylation BP
GO:0008168 methyltransferase activity MF
GO:0005819 spindle CC
GO:0003729 mRNA binding MF

Sequence

>gi|19113021|ref|NP_596229.1| fibrillarin [Schizosaccharomyces pombe 972h-]
MAYTPGSRGGRGGSRGGRGGFNGGRGGFGGGRGGARGGGRGGARGGRGGRGGARGGRGGSSGGRGGAKGG
AKVIIEPHRHAGVFIARGKEDLLVTRNLVPGESVYNEKRISVDSPDGTKVEYRVWNPFRSKLAAGILGGL
DNIYIKPGARVLYLGAANGTSVSHVADVVGPEGLVYAVEFSHRSGRDLLNMAKKRTNVIPIVEDARHVQK
YRMLVGMVDVVFADVAQPDQARIVALNAAAFLKNEGGVVISVKASCIDSTADAAVVFAREVKKMQEEKIK
PQEQLTLEPYERDHCIIVGKYLRHQ

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq NP_596229.1
Pfam PF01269