transferase

General Information (Source: NCBI Gene,UniProt)

Text mining Term transferase
UniProt ID PRSN_PIEBR
Name Pierisin
Pierisin-B
NAD--DNA ADP-ribosyltransferase
Pierisin-2
Gene Names
Taxonomy Pieris brassicae

General annotation

Function Catalyzes the ADP ribosylation of double-stranded DNA by targeting the N2 amino group of dG residues. Induces apoptosis in a range of human cell lines.
Subcellular location

Gene Ontology

GO:0030591 NAD DNA ADP-ribosyltransferase activity MF
GO:0006917 induction of apoptosis BP
GO:0030592 DNA ADP-ribosylation BP
GO:0006915 apoptotic process BP

Sequence

>gi|25091033|sp|Q9GV36.1|PRSN_PIEBR RecName: Full=Pierisin; AltName: Full=NAD--DNA ADP-ribosyltransferase; AltName: Full=Pierisin-2; AltName: Full=Pierisin-B
MSNNPPYMTNGIQAAVVEWIRALDLEIISLLLSRAWPLALLTTTELRWRPTVLTDTDNVVRLDRRQRLVR
WDRRPPNEIFLEGFVPIVTREDPDWEETDLYGFAKNNHPSIFVSTTKTQRNKKKYVWTPRNANRGIVYQY
EIYAPGGVDVNDSFSDASPWPNQMEVAFPGGIQNIYIRSARELHNGRVQRIWINPNFLDPGDLEPIVSSS
RTLQVIWRVNHPDGGNKDGRSERSTSSYDDLMYGGTGNVQEDTFGDESNNPKPIADGEFMIESIKDKNSF
LDLSKNVNGGIIHSNVYSGGDNQIWVFSYDDNKKAYKIKSYQNSSLYLSWDSNASSKEIILRGYTNSGSN
NQYWQIEQTGKNYRLRNLLNLNMIITAQDKSSAFGGKEVIVNTEISNSNTKSSQEWNIIPFDFRPIMDGD
YNIFNLDLPNQVVDFSNQPDLLVHGHEFCDNENQTWHFTYNSTYHAYKIWSGRKSNLLLTWDSNATSKEM
VVRAYTESRSKNQYWRIEQTGSKSYKLRNLENSNMILGLTNVSTSYGGLNLMVQDDSNGNSNLHSDWDIK
PIIYQYVPDGDYNIFNDNFPNIAVDYTNQEGALVHGHNFCSNNNQKWSFVYDGKKKAYKIKSGVNSKLWL
TWDSNASSKEMVLRAYTESGNWNQYWRLYQANDGSYIIRNLKEFKMLIALTNIDTPYGGKQLIVTDTKES
GNHWYLKKLGEVPLPNRKFRIATKLNYKKVIDSSTAYNLIITHDLNFASSIWELVYDSNKKAYNIYSADI
NNLGWVYQNKNFFVKLDNIDGPDHGDLRYFWTIEYSMQTGCYLIRSLYDPAHAVGYTDKDSVITDTSTYS
DNQLFHFILM

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam PF05588
PF00652