| Text mining Term | protein is |
|---|---|
| UniProt ID | LSDA_DROME |
| Name |
Possible lysine-specific histone demethylase 1 |
| Gene Names |
|
| Taxonomy | Drosophila melanogaster |
| Function |
Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for heterochromatic gene silencing. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and tri- methylated 'Lys-4' of histone H3. May also demethylate 'Lys-9' of histone H3, Plays a role in the repression of neuronal genes. |
|---|---|
| Subcellular location |
Nucleus. Chromosome. Note=In early cleavage, protein displays a uniform nuclear distribution. At metaphase, protein is detected at the chromosome periphery, and between the chromosomes during anaphase. A rather uniform interphase chromatin association is detected until syncytial blastoderm. When cellular blastoderm is formed (cycle 14), protein is preferably associated with pericentric heterochromatin situated at the apical pole of blastoderm nuclei. Later in development, protein is only found over euchromatin. In the germline precursor pole cells, protein remains uniformly distributed within the nucleus. |
| GO:0050660 | flavin adenine dinucleotide binding | MF |
| GO:0034720 | histone H3-K4 demethylation | BP |
| GO:0005515 | protein binding | MF |
| GO:0006351 | transcription, DNA-dependent | BP |
| GO:0007474 | imaginal disc-derived wing vein specification | BP |
| GO:0048477 | oogenesis | BP |
| GO:0005694 | chromosome | CC |
| GO:0016458 | gene silencing | BP |
| GO:0008593 | regulation of Notch signaling pathway | BP |
| GO:0016491 | oxidoreductase activity | MF |
| GO:0070828 | heterochromatin organization | BP |
| GO:0005634 | nucleus | CC |
| GO:0006355 | regulation of transcription, DNA-dependent | BP |
>gi|75027620|sp|Q9VW97.1|LSDA_DROME RecName: Full=Possible lysine-specific histone demethylase 1 MKPTQFGGSSSKMTEPIEYVTLISDDSDGEPTPKRNVNHPPSALSAPNPGQKQKHPDEDSNDAPATSDER RTSRRNRPKVDYSNRPSGSGDTASNDKSGSASMGPNNQQAERRSQSQTRKSEANATSSSVSGPSAGNSRP SQNGDSKDRDAGTPTVLSGQEGAVFQSRLPFNKMTPNEEACFPDISRSGILGHRVFLNIRNSLLHMWVDN PKIQLSFEIALKNLPPPFDSEPSLVRRVHSFLERHGFINFGIFKRLKPIPAKKLGKVIVIGAGISGLAVA HQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPLYG PDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEI IATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDL HAEEKQMLAKLHELEQNRPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTV RNGYSCVPVALTENLDIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHK ESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASRGEMFLFWSISS SPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSS GSDYDLLAAPVIPPSSKDAEGLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADYYLGYPEGTPPDIG YSVAEAANLVSVGNVVKLRDLSPNLSDSSPSSKKSEENSNSNTADSTELQ |
| Ensembl Gene | |
|---|---|
| UniGene |
Dm.11528 |
| PDB | |
| RefSeq |
NP_730497.1 NP_649194.1 |
| Pfam |
PF04433 PF01593 |