protein is

General Information (Source: NCBI Gene,UniProt)

Text mining Term protein is
UniProt ID LSDA_DROME
Name Possible lysine-specific histone demethylase 1
Gene Names
Taxonomy Drosophila melanogaster

General annotation

Function Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for heterochromatic gene silencing. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and tri- methylated 'Lys-4' of histone H3. May also demethylate 'Lys-9' of histone H3, Plays a role in the repression of neuronal genes.
Subcellular location Nucleus. Chromosome. Note=In early cleavage, protein displays a uniform nuclear distribution. At metaphase, protein is detected at the chromosome periphery, and between the chromosomes during anaphase. A rather uniform interphase chromatin association is detected until syncytial blastoderm. When cellular blastoderm is formed (cycle 14), protein is preferably associated with pericentric heterochromatin situated at the apical pole of blastoderm nuclei. Later in development, protein is only found over euchromatin. In the germline precursor pole cells, protein remains uniformly distributed within the nucleus.

Gene Ontology

GO:0007474 imaginal disc-derived wing vein specification BP
GO:0050660 flavin adenine dinucleotide binding MF
GO:0008593 regulation of Notch signaling pathway BP
GO:0016491 oxidoreductase activity MF
GO:0006355 regulation of transcription, DNA-dependent BP
GO:0016458 gene silencing BP
GO:0048477 oogenesis BP
GO:0006351 transcription, DNA-dependent BP
GO:0005634 nucleus CC
GO:0034720 histone H3-K4 demethylation BP
GO:0005694 chromosome CC
GO:0070828 heterochromatin organization BP
GO:0005515 protein binding MF

Sequence

>gi|75027620|sp|Q9VW97.1|LSDA_DROME RecName: Full=Possible lysine-specific histone demethylase 1
MKPTQFGGSSSKMTEPIEYVTLISDDSDGEPTPKRNVNHPPSALSAPNPGQKQKHPDEDSNDAPATSDER
RTSRRNRPKVDYSNRPSGSGDTASNDKSGSASMGPNNQQAERRSQSQTRKSEANATSSSVSGPSAGNSRP
SQNGDSKDRDAGTPTVLSGQEGAVFQSRLPFNKMTPNEEACFPDISRSGILGHRVFLNIRNSLLHMWVDN
PKIQLSFEIALKNLPPPFDSEPSLVRRVHSFLERHGFINFGIFKRLKPIPAKKLGKVIVIGAGISGLAVA
HQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPLYG
PDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEI
IATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDL
HAEEKQMLAKLHELEQNRPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTV
RNGYSCVPVALTENLDIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHK
ESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASRGEMFLFWSISS
SPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSS
GSDYDLLAAPVIPPSSKDAEGLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADYYLGYPEGTPPDIG
YSVAEAANLVSVGNVVKLRDLSPNLSDSSPSSKKSEENSNSNTADSTELQ

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.11528
PDB
RefSeq NP_649194.1
NP_730497.1
Pfam PF01593
PF04433