glyoxalase I

General Information (Source: NCBI Gene,UniProt)

Text mining Term glyoxalase I
UniProt ID LGUL_SCHPO
Name Glyoxalase I
S-D-lactoylglutathione methylglyoxal lyase
Glx I
Aldoketomutase
Lactoylglutathione lyase
Methylglyoxalase
Ketone-aldehyde mutase
Gene Names glo1
Taxonomy Schizosaccharomyces pombe 972h-

General annotation

Function Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
Subcellular location

Gene Ontology

GO:0006749 glutathione metabolic process BP
GO:0004462 lactoylglutathione lyase activity MF
GO:0019243 methylglyoxal catabolic process to D-lactate BP
GO:0008270 zinc ion binding MF
GO:0005634 nucleus CC
GO:0005829 cytosol CC
GO:0071470 cellular response to osmotic stress BP

Sequence

>gi|19112802|ref|NP_596010.1| glyoxalase I [Schizosaccharomyces pombe 972h-]
MASTTDMSTYKLNHTMIRVKDLDKSLKFYTEVFGMKLIDQWVFEENEFSLSFLAFDGPGALNHGVERSKR
EGILELTYNFGTEKKEGPVYINGNTEPKRGFGHICFTVDNIESACAYLESKGVSFKKKLSDGKMKHIAFA
LDPDNYWIELVSQSETKPKANISNFRFNHTMVRVKDPEPSIAFYEKLGMKVIDKADHPNGKFTNYFLAYP
SDLPRHDREGLLELTHNWGTEKESGPVYHNGNDGDEKGYGHVCISVDNINAACSKFEAEGLPFKKKLTDG
RMKDIAFLLDPDNYWVEVIEQK

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq NP_596010.1
Pfam PF00903