ferrochelatase

General Information (Source: NCBI Gene,UniProt)

Text mining Term ferrochelatase
UniProt ID HEMH_SCHPO
Name Heme synthase
Protoheme ferro-lyase
Ferrochelatase, mitochondrial
Gene Names
Taxonomy Schizosaccharomyces pombe 972h-

General annotation

Function Catalyzes the ferrous insertion into protoporphyrin IX (By similarity).
Subcellular location Mitochondrion inner membrane. Note=Bound to the mitochondrial inner membrane in eukaryotic cells with its active site on the matrix side of the membrane (By similarity).

Gene Ontology

GO:0005829 cytosol CC
GO:0006783 heme biosynthetic process BP
GO:0004325 ferrochelatase activity MF
GO:0005634 nucleus CC
GO:0046872 metal ion binding MF
GO:0051537 2 iron, 2 sulfur cluster binding MF
GO:0005743 mitochondrial inner membrane CC

Sequence

>gi|19075220|ref|NP_587720.1| ferrochelatase [Schizosaccharomyces pombe 972h-]
MSVSSYSSDASSTVMDESPPNGVTKSVSGKGPTAVVMMNMGGPSNLDEVGPFLERLFTDGDIIPLGYFQN
SLGKFIAKRRTPKVQNHYSDIGGGSPILHWTRIQGSEMCKILDKKCPESAPHLPFVAFRYAPPLTEDMLD
ELKKANVSRAVAFSQYPQWSCATSGASLNELRRKLIEKGMEKDFEWSIVDRWPLQQGLINAFAENIEETL
KTYPEDVRDDVVIVFSAHSLPMSQVAKGDPYVYEIAATSQAVMKRLNYKNKFVNAWQSKVGPLPWMSPAT
DFVIEQLGNRGQKNMILVPIAFTSDHIETLKELEDYIEDAKQKGITGVKRVSSINGSMTAIQGMADLVAE
HLKAKVPYSRQFTQRCPGCTSESCAERINFFQDF

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq NP_587720.1
Pfam PF00762