Tyrosinase

General Information (Source: NCBI Gene,UniProt)

Text mining Term Tyrosinase
UniProt ID PRP2_MANSE
Name Phenoloxidase subunit 2
proPO-p2
Gene Names ppo
Taxonomy Manduca sexta

General annotation

Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone. Binds to the surface of hemocytes and is involved in hemocyte melanization.
Subcellular location Secreted.

Gene Ontology

GO:0005507 copper ion binding MF
GO:0005344 oxygen transporter activity MF
GO:0004503 monophenol monooxygenase activity MF
GO:0006952 defense response BP
GO:0031404 chloride ion binding MF
GO:0035008 positive regulation of melanization defense response BP
GO:0006583 melanin biosynthetic process from tyrosine BP
GO:0005576 extracellular region CC

Sequence

>gi|75038472|sp|Q25519.3|PRP2_MANSE RecName: Full=Phenoloxidase subunit 2; AltName: Full=proPO-p2
MADIFDSFELLYDRPGEPMINTKGEDKVLFELTEQFLTPEYANNGLELNNRFGDEEEVSRKIILKNLDKI
PEFPKAKQLPNDADFSLFLPSHQEMANEVIDVLMSVTENQLQELLSTCVYARINLNPQLFNYCYTVAIMH
RRDTGKVRVQNYAEIFPAKFLDSQVFTQAREAAAVIPKTIPRTPIIIPRDYTATDLEEEHRLAYWREDLG
INLHHWHWHLVYPFSASDEKIVAKDRRGELFFYMHQQIIARYNCERLCNSLKRVKKFSDWREPIPEAYYP
KLDSLTSARGWPPRQAGMRWQDLKRPVDGLNVTIDDMERYRRNIEEAIATGNVILPDKSTKKLDIDMLGN
MMEASVLSPNRDLYGSIHNNMHSFSAYMHDPEHRYLESFGVIADEATTMRDPFFYRVHAWVDDIFQSFKE
APHNVRPYSRSQLENPGVQVTSVAVESAGGQQNVLNTFWMQSDVNLSKGLDFSDRGPVYARFTHLNHRPF
RYVIKANNTASARRTTVRIFIAPKTDERNLPWALSDQRKMFIEMDRFVVPLSAGENTITRQSTESSLTIP
FEQTFRDLSIQGSDPRRSELAAFNYCGCGWPQHMLVPKGTVGGVAYQLFVMLSNYELDKIEQPDGRELSC
VEASMFCGLKDKKYPDARPMGYPFDRPSNSATNIEDFSAMSNMGLQDIVIKLSDVTEPNPRNPPA

Options for BLAST

Database:

Set subsequence:(optional):
From: To:

Optional parameters:
Expect:
Descriptions:

Database Cross Reference

Ensembl Gene
UniGene
PDB 3HHS
RefSeq
Pfam PF00372
PF03723
PF03722