Tyrosinase

General Information (Source: NCBI Gene,UniProt)

Text mining Term Tyrosinase
UniProt ID PRP2_MANSE
Name Phenoloxidase subunit 2
proPO-p2
Gene Names ppo
Taxonomy Manduca sexta

General annotation

Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone. Binds to the surface of hemocytes and is involved in hemocyte melanization.
Subcellular location Secreted.

Gene Ontology

GO:0035008 positive regulation of melanization defense response BP
GO:0005507 copper ion binding MF
GO:0031404 chloride ion binding MF
GO:0005344 oxygen transporter activity MF
GO:0005576 extracellular region CC
GO:0004503 monophenol monooxygenase activity MF
GO:0006952 defense response BP
GO:0006583 melanin biosynthetic process from tyrosine BP

Sequence

>gi|75038472|sp|Q25519.3|PRP2_MANSE RecName: Full=Phenoloxidase subunit 2; AltName: Full=proPO-p2
MADIFDSFELLYDRPGEPMINTKGEDKVLFELTEQFLTPEYANNGLELNNRFGDEEEVSRKIILKNLDKI
PEFPKAKQLPNDADFSLFLPSHQEMANEVIDVLMSVTENQLQELLSTCVYARINLNPQLFNYCYTVAIMH
RRDTGKVRVQNYAEIFPAKFLDSQVFTQAREAAAVIPKTIPRTPIIIPRDYTATDLEEEHRLAYWREDLG
INLHHWHWHLVYPFSASDEKIVAKDRRGELFFYMHQQIIARYNCERLCNSLKRVKKFSDWREPIPEAYYP
KLDSLTSARGWPPRQAGMRWQDLKRPVDGLNVTIDDMERYRRNIEEAIATGNVILPDKSTKKLDIDMLGN
MMEASVLSPNRDLYGSIHNNMHSFSAYMHDPEHRYLESFGVIADEATTMRDPFFYRVHAWVDDIFQSFKE
APHNVRPYSRSQLENPGVQVTSVAVESAGGQQNVLNTFWMQSDVNLSKGLDFSDRGPVYARFTHLNHRPF
RYVIKANNTASARRTTVRIFIAPKTDERNLPWALSDQRKMFIEMDRFVVPLSAGENTITRQSTESSLTIP
FEQTFRDLSIQGSDPRRSELAAFNYCGCGWPQHMLVPKGTVGGVAYQLFVMLSNYELDKIEQPDGRELSC
VEASMFCGLKDKKYPDARPMGYPFDRPSNSATNIEDFSAMSNMGLQDIVIKLSDVTEPNPRNPPA

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Database Cross Reference

Ensembl Gene
UniGene
PDB 3HHS
RefSeq
Pfam PF03722
PF00372
PF03723