tumor necrosis factor alpha

General Information (Source: NCBI Gene,UniProt)

Text mining Term tumor necrosis factor alpha
UniProt ID ADA17_DROME
Name ADAM 17-like protease
Gene Names Tace
Taxonomy Drosophila melanogaster

General annotation

Function
Subcellular location Membrane; Single-pass type I membrane protein (Potential).

Gene Ontology

GO:0004222 metalloendopeptidase activity MF
GO:0016021 integral to membrane CC
GO:0006508 proteolysis BP
GO:0008270 zinc ion binding MF

Sequence

>gi|47117671|sp|Q9VAC5.2|ADA17_DROME RecName: Full=ADAM 17-like protease; Flags: Precursor
MFTKCISCCGLAIISVFFACLFVENCAALQKTLRHYEIFHKDDVVHRVVKRGAKHSTNPFNTIKEVEFTT
LGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLP
EETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYIKEGLELEDKEHGDTLDNELHTREK
RQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMG
FVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGS
PRRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPECSPSA
SQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGTE
DNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADG
TTCQERGQCRNGKCVPYCETQGLQSCMCDIIADACKRCCRMSINETCFPVEPPDVLPDGTPCITGFCNKG
VCEKTIQDVVERFWDIIEEINVAKTLRFLKDNIVMAVVLVTAVFWIPISCVISYFDRKKLRHEMKLIEWS
QKLDLIHPSDERRRVIHIRVPRQKISVARACN

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.6531
PDB
RefSeq NP_651759.4
NP_733334.1
Pfam PF01562
PF00200
PF01421