sterol 14 alpha demethylase

General Information (Source: NCBI Gene,UniProt)

Text mining Term sterol 14 alpha demethylase
UniProt ID CP51_USTMA
Name Cytochrome P450 51
CYPLI
Cytochrome P450-14DM
Sterol 14-alpha demethylase
Lanosterol 14-alpha demethylase
Cytochrome P450-LIA1
Gene Names ERG11
Synonyms:CYP51
Taxonomy Ustilago maydis 521

General annotation

Function Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).
Subcellular location Membrane (Potential).

Gene Ontology

GO:0016126 sterol biosynthetic process BP
GO:0016020 membrane CC
GO:0020037 heme binding MF
GO:0009055 electron carrier activity MF
GO:0008398 sterol 14-demethylase activity MF

Sequence

>gi|71019157|ref|XP_759809.1| sterol 14-alpha demethylase [Ustilago maydis 521]
MVASSSSATASLLDQLFALTPLADSSAWIKTITVLVLLPLLAVVLNVASQLLLATPKNHPPVVFHFVPVI
GSAIYYGIDPYKFFFECREKYGDVFTFVLLGRKITVALGPKGSNLVFNAKHQQVTAEDAYTHLTTPVFGK
EVVYDVPNAVFMEQKKFVKVGLSIENFRVYVPQIVDEVREYIKSDARFSALKTRKTITVDIFQAMSELII
LTASRTLQGKEVRQGLDKSFAQLYHDLDSGFTPINFVIPNLPLPSNFKRDRAQKKMSQFYQDIVAKRRAA
GASTSADDASGENDMIAALIEQKYKNGRALSGVEIAHMMIALLMAGQHTSSATSSWAFLRLASRPEIIEE
LYEEQLNVYSDGHGGLRELDYETQKTSVPLLDAVVKETLRLHPPLHSIMRYVKSDLAVPPTLSSPTSTKS
EPDAHYVIPKGHYIMAAPGVSQVDPQIWKSSDQFDPHRWLDATTAAAMQDSGEDKQDFGFGMISTGANSP
YLPFGAGRHRCIGEQFAYLQIGVILATFVRIFKWHLDSKFPDPDYQSMVVLPSKNGCAIVLTPRAESLHL
D

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq XP_759809.1
Pfam PF00067