choline acetyltransferase

General Information (Source: NCBI Gene,UniProt)

Text mining Term choline acetyltransferase
UniProt ID CLAT_DROME
Name CHOACTase
ChAT
Choline O-acetyltransferase 13 kDa chain
Choline O-acetyltransferase 54 kDa chain
Choline O-acetyltransferase 67 kDa chain
Choline acetylase
Choline O-acetyltransferase
Gene Names Cha
Taxonomy Drosophila melanogaster

General annotation

Function Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Subcellular location

Gene Ontology

GO:0007399 nervous system development BP
GO:0005634 nucleus CC
GO:0008292 acetylcholine biosynthetic process BP
GO:0005829 cytosol CC
GO:0007274 neuromuscular synaptic transmission BP
GO:0004102 choline O-acetyltransferase activity MF

Sequence

>gi|61679360|gb|AAS65177.2| choline acetyltransferase, isoform B [Drosophila melanogaster]
MASNEASTSAAGSGPESAALFSKLRSFSIGSGPNSPQRVVSNLRGFLTHRLSNITPSDTGWKDSILSIPK
KWLSTAESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYL
LDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVHDVAHFAARLLDGILSHREMLDSGE
LPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDRHVVVICRNQMYCVVLQASDR
GKLSESEIASQILYVLSDAPCLPAKPVPVGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLD
EPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHS
CSEGIAVVQLLEKIYKKIEEHPDEDNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVY
RYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAM
CQGEGANVPLESDREDEEESRKKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHE
LFKDESYIISQCFLLSTSQVACSTDSFMGYGPVTPRGYGCSYNPHPEQIVFCVSAFYSCEDTSASRYAKS
LQDSLDIMRDLLQN

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.1244
PDB
RefSeq NP_996239.2
NP_477004.5
Pfam PF00755