frataxin

General Information (Source: NCBI Gene,UniProt)

Text mining Term frataxin
UniProt ID FRDA_SCHPO
Name Frataxin homolog, mitochondrial
Gene Names
Taxonomy Schizosaccharomyces pombe 972h-

General annotation

Function Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (By similarity).
Subcellular location Mitochondrion (By similarity).

Gene Ontology

GO:0072592 oxygen metabolic process BP
GO:0006879 cellular iron ion homeostasis BP
GO:0006783 heme biosynthetic process BP
GO:0004322 ferroxidase activity MF
GO:0018283 iron incorporation into metallo-sulfur cluster BP
GO:0005759 mitochondrial matrix CC
GO:0030234 enzyme regulator activity MF
GO:0006811 ion transport BP
GO:0005506 iron ion binding MF

Sequence

>gi|19075386|ref|NP_587886.1| frataxin [Schizosaccharomyces pombe 972h-]
MQSLRAAFRRRTPIFLKPYEFSTNVFGLRCRYYSQVRHNGALTDLEYHRVADDTLDVLNDTFEDLLEEVG
KKDYDIQYANGVITLMLGEKGTYVINKQPPAHQIWLSSPVSGPKHYEYSLKSKTWCSTRDEGTLLGILSS
EFSKWFSRPIEFKKSEDF

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq NP_587886.1
Pfam PF01491