metalloproteinase

General Information (Source: NCBI Gene,UniProt)

Text mining Term metalloproteinase
UniProt ID NPIIC_ASPFU
Name Neutral protease 2 homolog AFUB_070680
Deuterolysin AFUB_070680
Gene Names
Taxonomy Aspergillus fumigatus Af293

General annotation

Function Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine. May be involved in virulence (By similarity).
Subcellular location Secreted (By similarity).

Gene Ontology

GO:0006508 proteolysis BP
GO:0004222 metalloendopeptidase activity MF
GO:0009405 pathogenesis BP
GO:0046872 metal ion binding MF
GO:0005576 extracellular region CC

Sequence

>gi|146323601|ref|XP_746456.2| metalloproteinase [Aspergillus fumigatus Af293]
MSIDINLRVTQHVWQHEHPHQHHKSKPKRIMKITALASAILAVAQGALALPARAPALDITLSQVNNTRIK
AVVKNSGTEKITFVHLNFFNDPSPVKKVSLYRNATEVEFTGIKQRLRSDGLSNDALTTLAPGATYEDEFD
IASTANLTQGGPVTVRTQGFVPIAMNNKIAGYIPYSSNELELEVDAEKAVAVPASIKPLDRRTKITSSCT
GNRATVLNTALRNAASIASKAADAASSGSSALFTEYFKSTSGNIRSAVAARLKAVASEASMNGGGSTTYY
CSDPYGYCDSNVLAYTLPSTNEVVNCELFYTLQEVTNDCHGQDQATTIIHEFTHAPGVYPPGTEDLGYGY
SAATALSTSNALNNADSYALFANAVYLNCQGQTGGQTTWDGYSQPGQTEPGTQTMWDGYSQPGQTEPGTQ
TMWDGYSQPGQTEPGTQTTWDGYSQPGQIEPCTQTMWDGGSEPGQTEPDAQTMWDNFYQA

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq XP_746456.2
Pfam PF02102