interleukin 1 beta

General Information (Source: NCBI Gene,UniProt)

Text mining Term interleukin 1 beta
UniProt ID CASP8_DROME
Name Caspase-8 subunit p15
Caspase-8
Death-related ced-3/NEDD2-like protein
Caspase-8 subunit p10
Gene Names Dredd
Synonyms:DCP2
Taxonomy Drosophila melanogaster

General annotation

Function Effector of the programmed cell death (PCD) activators rpr, grim and W. May play an apoptotic role in the germline as well as soma. Role in immune response, required to resist Gram- negative bacterial infections by regulating Dpt. BG4 interacts with Dredd, BG4 promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.
Subcellular location Cytoplasm.

Gene Ontology

GO:0006508 proteolysis BP
GO:0048935 peripheral nervous system neuron development BP
GO:0004197 cysteine-type endopeptidase activity MF
GO:0005515 protein binding MF
GO:0006963 positive regulation of antibacterial peptide biosynthetic process BP
GO:0045087 innate immune response BP
GO:0006915 apoptotic process BP
GO:0016485 protein processing BP
GO:0050829 defense response to Gram-negative bacterium BP
GO:0007291 sperm individualization BP
GO:0005737 cytoplasm CC
GO:0016505 apoptotic protease activator activity MF
GO:0061057 peptidoglycan recognition protein signaling pathway BP

Sequence

>gi|239938914|sp|Q8IRY7.3|CASP8_DROME RecName: Full=Caspase-8; AltName: Full=Death-related ced-3/NEDD2-like protein; Contains: RecName: Full=Caspase-8 subunit p15; Contains: RecName: Full=Caspase-8 subunit p10; Flags: Precursor
MAGSNLLIHLDTIDQNDLIYVERDMNFAQKVGLCFLLYGDDHSDATYILQKLLAMTRSDFPQSDLLIKFA
KSRPETWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGITLHVHPLLKSLYRMCEELSLVQSGR
LLLDVREKVESQQAGDPLRFYDPAYLEIFLLDWLTRRSIKLGDINAAGSDVQLLVGHLKSNGLQAQANLL
KDTIISNAPEPDAAGTAAMAVKQEIESDNQQSYCSTQIDALKLTRENAGIALIINQQKFHRNVSRDNMKF
LSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMGIIERIRSACDRSLVRDSLVVFILSHGFEEA
VYASNSIAMKITDIEDLLCSYDTLYYKPKLLIIQACQEKLVHKKKPNELFRIDVTTVSPDQHIDMLRAMS
TVNGYAALRHTQTGSWFIGSLCDAIDRRSASEHIADILTIVTNEVSKKRGSNDESMVPNVKSTFRQHVYF
PPRL

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.3088
PDB
RefSeq NP_477249.3
NP_477251.3
NP_477250.3
Pfam PF00656