demethylase

General Information (Source: NCBI Gene,UniProt)

Text mining Term demethylase
UniProt ID CP51_WHEAT
Name Cytochrome P450-LIA1
Cytochrome P450 51
CYPLI
Obtusifoliol 14-alpha demethylase
Gene Names CYP51
Taxonomy Triticum aestivum

General annotation

Function Catalyzes the 14-alpha demethylation of obtusifoliol to 4 alpha-methyl-5 alpha-ergosta-8,14,24(28)-trien-3 beta-ol.
Subcellular location Membrane (Potential). Membrane; Single-pass membrane protein.

Gene Ontology

GO:0008168 methyltransferase activity MF
GO:0016126 sterol biosynthetic process BP
GO:0009055 electron carrier activity MF
GO:0020037 heme binding MF
GO:0016020 membrane CC
GO:0008398 sterol 14-demethylase activity MF

Sequence

>gi|6166036|sp|P93596.1|CP51_WHEAT RecName: Full=Obtusifoliol 14-alpha demethylase; AltName: Full=CYPLI; AltName: Full=Cytochrome P450 51; AltName: Full=Cytochrome P450-LIA1
RPPPTIPGAPVVGGLLRFLRGPIPLIRAEYARLGPVFTVPILTRRITFLIGPDVSAHFFKSNESDMSQQE
VYRFNVPTFGPGVVFDVDYQVRQEQFRFFTEALRANKLRSYVDQMVAEAEEYFSKWGESGTVDLKYELEH
LIILTASRCLLGREVREKLFDDVSALFHDLDNGMLPISVIFPYLPIPAHRRRDQARTRLAEIFATIIKSR
KASGQSEEDMLQCFIDSKYKNGRQTTESEVTGLLIAALFAGQHTSSITSTWTGAYLLKFQQYFAEAVEEQ
KEVMKRHGDKIDHDILAEMDVLYRCIKEALRLHPPLIMLLRQSHSDFSVTTREGKEFDIPKGHIVATSPA
FANRLPHIFKNPDSYDPDRFAAGREEDKVAGAFSYISFGGGRHGCLGEPFAYLQIKAIWTHLLRNFEFEL
VSPFPENDWNAMVVGIKGEVMVNYKRRKLIVDN

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam PF00067