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spinosad

Identification (Source:EPA,EU)

ID	1449
Name	spinosad
CAS	168316-95-8 (131929-60-7 + 131929-63-0)
IUPAC
Inchi	InChI=1S/C41H65NO10/c1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m1/s1
CIPAC	636
EPA Code	110003
Formula	C41H65NO10 (spinosyn A) + C42H67NO10 (spinosyn D)
SMILES	C[C@@H]6[C@@H](O[C@H]1CC[C@@H]([C@@H](C)O1)N(C)C)CCC[C@H](CC)OC(=O)C[C@@H]5C(=C/[C@@H]3[C@H]5/C=C(/C)[C@@H]2C[C@H](C[C@H]23)O[C@@H]4O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]4OC)\C6=O.CN(C)[C@H]1CC[C@@H](O[C@@H]1C)O[C@H]6CCC[C@H](CC)OC(=O)C[C@@H]5C(=C/[C@@H]3[C@H]5\C=C/[C@@H]2C[C@H](C[C@H]23)O[C@@H]4O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]4OC)\C(=O)[C@@H]6C
Status	Approved

Classification

Mode of Action	Contact and stomach action. Acts by exciting the insect nervous system, leading to involuntary muscle contractions and paralysis.
Pesticide Type	Insecticide
Chemical Group	Micro-organism derived
Classification	spinosyn insecticides

Properties (Source:PubChem)

Molecular Weight	739.0
Physical State	White-grey crystals
AlogP	5.638
H-Bond Donor	0
H-Bond Acceptor	10
Surface Area	731.39
Polar Surface Area	101.99

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	6.1 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	> 1.0 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.0012 mg l-1
Aquatic plants	Acute	7 day	EC50, biomass	10.6 mg l-1
Birds	Acute		LD50	> 2000 mg kg-1
Birds	Short term dietary		LC50/LD50	> 5156 mg/kg feed
Birds	Short term dietary		LC50/LD50	> 5156 mg/kg feed
Birds	Acute		LD50	> 2000 mg kg-1
Earthworms	Chronic	14 day	NOEC, reproduction	1.79 mg kg-1
Earthworms	Acute	14 day	LD50	> 458 mg kg-1
Fish	Acute	96 hour	LC50	30 mg l-1
Fish	Chronic	21 day	NOEC	0.5 mg l-1
Honeybees	Acute	48 hour	LD50	0.0036 μg bee-1
Mammals	Acute oral		LD50	> 2000 mg kg-1
Mammals	Acute oral		LD50	> 2000 mg kg-1
Mammals	Short term dietary		NOEL	9 mg kg-1
Mammals	Short term dietary		NOEL	9 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	0.0016 mg kg-1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	0.1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	0.1

Related targets

Target Name	RScore (About this table)
acetylcholine receptor (protein family or complex)	190(2,2,6,10)	Details
glutathione S transferase	88(1,1,2,3)	Details
Acetylcholinesterase	84(1,1,1,4)	Details
ATPase	83(1,1,1,3)	Details
cytochrome P450 monooxygenase	81(1,1,1,1)	Details
GABA receptor (protein family or complex)	39(0,1,2,4)	Details

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