Protein Information

Name Myosin
Synonyms Myosin

Compound Information

Name DDT
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
14514706 Lowe DA, Warren GL, Snow LM, Thompson LV, Thomas DD: Muscle activity and aging affect myosin structural distribution and force generation in rat fibers. J Appl Physiol. 2004 Feb;96(2):498-506. Epub 2003 Sep 26.

6(0,0,0,6) Details
18003749 Prochniewicz E, Lowe DA, Spakowicz DJ, Higgins L, O'Conor K, Thompson LV, Ferrington DA, Thomas DD: Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers. Am J Physiol Cell Physiol. 2008 Feb;294(2):C613-26. Epub 2007 Nov 14.

5(0,0,0,5) Details
15491680 Lowe DA, Husom AD, Ferrington DA, Thompson LV: Myofibrillar myosin ATPase activity in hindlimb muscles from young and aged rats. Mech Ageing Dev. 2004 Sep;125(9):619-27.

4(0,0,0,4) Details
19416073 Thomas DD, Kast D, Korman VL: Site-directed spectroscopic probes of actomyosin structural dynamics. Annu Rev Biophys. 2009;38:347-69.


Spectroscopy of myosin and actin has entered a golden age.
4(0,0,0,4) Details
15933379 Prochniewicz E, Thomas DD, Thompson LV: Age-related decline in actomyosin function. . J Gerontol A Biol Sci Med Sci. 2005 Apr;60(4):425-31.


To understand the molecular basis of the functional decline in aging muscle, we examined the functional (actomyosin ATPase) and chemical (cysteine content) changes in actin and myosin purified from the muscles of young (4- to 12-month-old) and old (27- to 35-month-old) Fisher 344 rats.
3(0,0,0,3) Details
17706387 Prochniewicz E, Thompson LV, Thomas DD: Age-related decline in actomyosin structure and function. . Exp Gerontol. 2007 Oct;42(10):931-8. Epub 2007 Jul 5.


This review focuses on the role of changes in the contractile proteins actin and myosin in age-related deterioration of skeletal muscle function.
3(0,0,0,3) Details
15311925 Prochniewicz E, Walseth TF, Thomas DD: Structural dynamics of actin during active interaction with myosin: different effects of weakly and strongly bound myosin heads. Biochemistry. 2004 Aug 24;43(33):10642-52.

3(0,0,0,3) Details
17964835 Surek JT, Thomas DD: A paramagnetic molecular voltmeter. J Magn Reson. 2008 Jan;190(1):7-25. Epub 2007 Oct 5.


Electrostatic potential is fundamental to energy-transducing proteins like myosin, because molecular energy storage and retrieval is primarily electrostatic.
2(0,0,0,2) Details
17545237 Espinoza-Fonseca LM, Kast D, Thomas DD: Molecular dynamics simulations reveal a disorder-to-order transition on phosphorylation of smooth muscle myosin. Biophys J. 2007 Sep 15;93(6):2083-90. Epub 2007 Jun 1.

2(0,0,0,2) Details