Protein Information

Name acetylcholine receptor (protein family or complex)
Synonyms Acetylcholine receptor; Acetylcholine receptors

Compound Information

Name DDT
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
16364641 Espinoza-Fonseca LM, Trujillo-Ferrara JG: The existence of a second allosteric site on the M1 muscarinic acetylcholine receptor and its implications for drug design. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1217-20. Epub 2005 Dec 20.

2(0,0,0,2) Details
16310776 Espinoza-Fonseca LM, Trujillo-Ferrara JG: Identification of multiple allosteric sites on the M1 muscarinic acetylcholine receptor. FEBS Lett. 2005 Dec 19;579(30):6726-32. Epub 2005 Nov 21.

2(0,0,0,2) Details
17935687 Espinoza-Fonseca LM, Pedretti A, Vistoli G: Structure and dynamics of the full-length M1 muscarinic acetylcholine receptor studied by molecular dynamics simulations. Arch Biochem Biophys. 2008 Jan 1;469(1):142-50. Epub 2007 Sep 15.

1(0,0,0,1) Details
16621535 Espinoza-Fonseca LM, Trujillo-Ferrara JG: Fully flexible docking models of the complex between alpha7 nicotinic receptor and a potent heptapeptide inhibitor of the beta-amyloid peptide binding. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3519-23. Epub 2006 Apr 18.


The heptapeptide IQTTWSR (IQ), recently reported as inhibitor of the beta-amyloid (Abeta) binding to nicotinic acetylcholine receptors (nAChrs), was docked to the homology model of the alpha7 nicotinic acetylcholine receptor.
1(0,0,0,1) Details