Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name DDT
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
15491680 Lowe DA, Husom AD, Ferrington DA, Thompson LV: Myofibrillar myosin ATPase activity in hindlimb muscles from young and aged rats. Mech Ageing Dev. 2004 Sep;125(9):619-27.

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15933379 Prochniewicz E, Thomas DD, Thompson LV: Age-related decline in actomyosin function. . J Gerontol A Biol Sci Med Sci. 2005 Apr;60(4):425-31.


To understand the molecular basis of the functional decline in aging muscle, we examined the functional (actomyosin ATPase) and chemical (cysteine content) changes in actin and myosin purified from the muscles of young (4- to 12-month-old) and old (27- to 35-month-old) Fisher 344 rats.
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16574147 Karim CB, Zhang Z, Howard EC, Torgersen KD, Thomas DD: Phosphorylation-dependent conformational switch in spin-labeled phospholamban bound to SERCA. J Mol Biol. 2006 May 12;358(4):1032-40. Epub 2006 Mar 9.


We have used chemical synthesis, functional reconstitution, and electron paramagnetic resonance (EPR) to probe the functional dynamics of phospholamban (PLB), which regulates the Ca-ATPase (SERCA) in cardiac sarcoplasmic reticulum.
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19416073 Thomas DD, Kast D, Korman VL: Site-directed spectroscopic probes of actomyosin structural dynamics. Annu Rev Biophys. 2009;38:347-69.


We emphasize studies that probe directly the movements of structural elements within the myosin catalytic and light-chain domains, and changes in the dynamics of both actin and myosin due to their alternating strong and weak interactions in the ATPase cycle.
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15311925 Prochniewicz E, Walseth TF, Thomas DD: Structural dynamics of actin during active interaction with myosin: different effects of weakly and strongly bound myosin heads. Biochemistry. 2004 Aug 24;43(33):10642-52.


We have used optical spectroscopy (transient phosphorescence anisotropy, TPA, and fluorescence resonance energy transfer, FRET) to detect the effects of weakly bound myosin S1 on actin during the actomyosin ATPase cycle.
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17706387 Prochniewicz E, Thompson LV, Thomas DD: Age-related decline in actomyosin structure and function. . Exp Gerontol. 2007 Oct;42(10):931-8. Epub 2007 Jul 5.


Contractile proteins from aged and young muscle differ in (a) myosin and actomyosin ATPase activities, (b) structural states of myosin in contracting muscle, (c) the state of oxidative modifications.
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