| Name | ERbeta |
|---|---|
| Synonyms | ER beta; ERb; ERbeta; ESR beta; ESR 2; ESR2; ESRB; ESRbeta… |
| Name | DDT |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18195494 | Wojtowicz AK, Kajta M, Gregoraszczuk EL: DDT- and DDE-induced disruption of ovarian steroidogenesis in prepubertal porcine ovarian follicles: a possible interaction with the main steroidogenic enzymes and estrogen receptor beta. J Physiol Pharmacol. 2007 Dec;58(4):873-85. |
3(0,0,0,3) | Details |
| 16626760 | Lemaire G, Mnif W, Mauvais P, Balaguer P, Rahmani R: Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. Life Sci. 2006 Aug 15;79(12):1160-9. Epub 2006 Mar 27. In this report, forty-nine pesticides were tested for ERalpha and beta activation or inhibition in stable reporter cell lines, HELN ERalpha and ERbeta. |
3(0,0,0,3) | Details |
| 18700809 | Wang L, Zhou S, Lin K, Zhao M, Liu W, Gan J: Enantioselective estrogenicity of o,p'-dichlorodiphenyltrichloroethane in the MCF-7 human breast carcinoma cell line. Environ Toxicol Chem. 2009 Jan;28(1):1-8. The cell proliferation, the up-regulation of pS2, and the down-regulation of ERalpha and ERbeta gene expressions induced by the racemate and enantiomers of o,p'-DDT were all reversed by cotreatment with 10 (-6) mol/L ICI 182,780. |
2(0,0,0,2) | Details |
| 17949972 | Blum JL, James MO, Stuchal LD, Denslow ND: Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells. J Steroid Biochem Mol Biol. 2008 Jan;108(1-2):55-63. Epub 2007 Sep 7. While it is clear the ERbeta subtypes are the products of different genes (due to a gene duplication in teleosts) the differences in their responses to MXC and its metabolites indicate that their functions diverge, both in their in vivo molecular response to E (2), as well as in their interaction with endocrine disrupting compounds found in the wild. |
1(0,0,0,1) | Details |
| 20064516 | Katsu Y, Taniguchi E, Urushitani H, Miyagawa S, Takase M, Kubokawa K, Tooi O, Oka T, Santo N, Myburgh J, Matsuno A, Iguchi T: Molecular cloning and characterization of ligand- and species-specificity of amphibian estrogen receptors. Gen Comp Endocrinol. 2010 Jan 12. To understand the molecular mechanisms of action and to evaluate estrogen receptor ligand interactions in amphibians, we isolated cDNAs encoding the estrogen receptors (ERalpha and ERbeta) from the Japanese firebelly newt (Cynops pyrrhogaster), Tokyo salamander (Hynobius tokyoensis), axolotl (Ambystoma mexicanum), and Raucous toad (Bufo rangeri). |
1(0,0,0,1) | Details |
| 16329587 | Liu GH, Yang KD, Liu XP, Qin QF: [Effects of residues of organochlorine pesticides on reproductive endocrine in human]. Wei Sheng Yan Jiu. 2005 Sep;34(5):524-8. However, the hormones, for example, LH in the women blood and P in the cords blood decreased respectively with the rising pesticides' levels and an obvious dose-effect relationship was found. (2) The expressional abundances of alpha-estrogen receptor (alpha-ER), beta-endorphin (beta-EP) and gonadotropin releasing hormone (GnRH) in the placentae and alpha-ER and beta-EP in the cord tissues went up respectively in dose-effect manner following the rising pesticides' burdens. (3) The times of the previous adverse pregnancy outcomes increased with the increase of the residues' burdens and there were significant differences between the control and various residue groups, but the times in the high-residue was smaller than that in the mid-residue group (P < 0.01). |
1(0,0,0,1) | Details |