Protein Information

Name PCNA
Synonyms Cyclin; DNA polymerase delta auxillary protein; PCNA; Proliferating cell nuclear antigen; DNA polymerase delta auxillary proteins; Proliferating cell nuclear antigens

Compound Information

Name DDT
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
18284681 Brun J, Chiu R, Lockhart K, Xiao W, Wouters BG, Gray DA: hMMS2 serves a redundant role in human PCNA polyubiquitination. BMC Mol Biol. 2008 Feb 19;9:24.

7(0,0,0,7) Details
18948756 Zhang S, Chea J, Meng X, Zhou Y, Lee EY, Lee MY: PCNA is ubiquitinated by RNF8. . Cell Cycle. 2008 Nov 1;7(21):3399-404.

6(0,0,0,6) Details
18157158 Andersen PL, Xu F, Xiao W: Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA. Cell Res. 2008 Jan;18(1):162-73.

3(0,0,0,3) Details
17493787 Bredhult C, Backlin BM, Olovsson M: Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro. Reprod Toxicol. 2007 Jun;23(4):550-9. Epub 2007 Mar 31.


Cell proliferation was studied using immunocytochemistry for PCNA expression and a 5-bromo-2'-deoxyuridine assay.
1(0,0,0,1) Details
18178771 Wen R, Torres-Acosta JA, Pastushok L, Lai X, Pelzer L, Wang H, Xiao W: Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response. Plant Cell. 2008 Jan;20(1):213-27. Epub 2008 Jan 4.


DNA damage tolerance (DDT) in budding yeast requires Lys-63-linked polyubiquitination of the proliferating cell nuclear antigen.
1(0,0,0,1) Details