| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | chlordecone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1705986 | Chaudhury S, Mehendale HM: Amplification of CCl4 toxicity by chlordecone: destruction of rat hepatic microsomal cytochrome P-450 subpopulation. J Toxicol Environ Health. 1991 Mar;32(3):277-94. |
82(1,1,1,2) | Details |
| 6198578 | Agarwal AK, Mehendale HM: CCl4-induced alterations in Ca++ homeostasis in chlordecone and phenobarbital pretreated animals. Life Sci. 1984 Jan 9;34(2):141-8. Cytochrome P-450 induction was greater with phenobarbital pretreatment than with chlordecone but the CCl4 induced destruction of cytochrome P-450 was almost similar in both groups and progressive with the dose of CCl4. |
82(1,1,1,2) | Details |
| 2469794 | Britton RS, Dolak JA, Glende EA Jr, Recknagel RO: Potentiation of carbon tetrachloride hepatotoxicity by chlordecone: dose-response relationships and increased covalent binding in vivo. J Biochem Toxicol. 1987 Spring;2:43-55. Chlordecone treatment also increased hepatic cytochrome P-450 levels by 67% and resulted in an increase in the covalent binding of [14-C]-CCl4-derived metabolites to microsomal protein and lipid in vivo. |
37(0,1,2,2) | Details |
| 6209127 | Agarwal AK, Mehendale HM: Perturbation of homeostasis by CCl4 in rats pretreated with chlordecone and phenobarbital. Environ Health Perspect. 1984 Aug;57:289-91. Induction of cytochrome P-450 was greater with phenobarbital treatment than with chlordecone, but the CCl4-induced destruction of P-450 was similar in both groups and was progressive with the dose of CCl4 and with time after CCl4 administration. |
31(0,1,1,1) | Details |
| 1717217 | Carpenter HM, Curtis LR: Low dose chlordecone pretreatment altered disposition without induction of cytochrome P-450. Drug Metab Dispos. 1991 May-Jun;19(3):673-8. |
8(0,0,1,3) | Details |
| 7513451 | Kocarek TA, Schuetz EG, Guzelian PS: Regulation of cytochrome P450 2B1/2 mRNAs by Kepone (chlordecone) and potent estrogens in primary cultures of adult rat hepatocytes on Matrigel. Toxicol Lett. 1994 Apr;71(2):183-96. |
7(0,0,1,2) | Details |
| 2435068 | Crouch LS, Ebel RE: Influence of chlordecone and mirex exposure on benzo [a] pyrene metabolism of rat-liver microsomes. Xenobiotica. 1987 Jan;17(1):25-34. Treatment with chlordecone resulted in a two- to three-fold increase in cytochrome P-450 content but the BP-hydroxylase activity per mg microsomal protein was unaffected. |
7(0,0,1,2) | Details |
| 2481745 | Lewandowski M, Levi P, Hodgson E: Induction of cytochrome P-450 isozymes by mirex and chlordecone. . J Biochem Toxicol. 1989 Fall;4(3):195-9. |
7(0,0,1,2) | Details |
| 3104120 | Ebel RE, Barlow RL, McGrath EA: Chloroform hepatotoxicity in the Mongolian gerbil. Fundam Appl Toxicol. 1987 Feb;8(2):207-16. At a dose of 500 microliter/kg, cytochrome P-450 and its reductase were decreased by about 25% in the chlordecone-induced gerbil. |
6(0,0,1,1) | Details |
| 2481348 | Mehendale HM: Mechanism of the lethal interaction of chlordecone and CCl4 at non-toxic doses. Toxicol Lett. 1989 Dec;49(2-3):215-41. Mechanisms such as induction of microsomal cytochrome P-450 by chlordecone and greater lipid peroxidation are inadequate to explain the remarkably powerful potentiation of toxicity and lethality. |
6(0,0,1,1) | Details |
| 1708849 | Mehendale HM: Potentiation of halomethane hepatotoxicity by chlordecone: a hypothesis for the mechanism. Med Hypotheses. 1990 Dec;33(4):289-99. Mechanisms such as induction of microsomal cytochrome P-450 by chlordecone and greater lipid peroxidation are inadequate to explain the remarkably powerful potentiation of halomethane toxicity. |
6(0,0,1,1) | Details |
| 2427030 | Bandiera S, Ryan DE, Levin W, Thomas PE: Age- and sex-related expression of cytochromes p450f and P450g in rat liver. Arch Biochem Biophys. 1986 Aug 1;248(2):658-76. Cytochrome P450f levels rise from less than 1% in young animals to approximately 7 and 14% of total cytochrome P450 in adult male and female rats, respectively. |
3(0,0,0,3) | Details |
| 1283232 | Dahlstrom-King L, Couture J, Plaa GL: Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis. Toxicol Lett. 1992 Dec;63(3):243-52. In the present study, the possible role of cytochrome P-450 in the ketone potentiation phenomenon was investigated. Phenobarbital, 3-methylcholanthrene, chlordecone or mirex were used as inducers, and SKF 525-A, piperonyl butoxide, or cobaltous as inhibitors of monooxygenase activity. |
3(0,0,0,3) | Details |
| 6178186 | Klingensmith JS, Mehendale HM: Potentiation of CCl4 lethality by chlordecone. . Toxicol Lett. 1982 Apr;11(1-2):149-54. The objective of the present study was to evaluate the effect of CD on CCl4 lethality and several parameters associated with cytochrome P-450 activity. |
2(0,0,0,2) | Details |
| 1715015 | Kocarek TA, Schuetz EG, Guzelian PS: Selective induction of cytochrome P450e by kepone (chlordecone) in primary cultures of adult rat hepatocytes. Mol Pharmacol. 1991 Aug;40(2):203-10. Kepone also resembled phenobarbital in these experiments, in that there were dose-dependent increases in the amounts of hepatocellular P450p, P450pcn2, P450PB-1, P450f, and -cytochrome P450 oxidoreductase mRNAs. |
1(0,0,0,1) | Details |
| 2425914 | Hewitt LA, Caille G, Plaa GL: Temporal relationships between biotransformation, detoxication, and chlordecone potentiation of chloroform-induced hepatotoxicity. Can J Physiol Pharmacol. 1986 Apr;64(4):477-82. At 2, 4, 8, 16, 20, 24, or 32 days posttreatment, groups of rats were killed and their livers were analyzed for (i) cytochrome P-450, -dependent cytochrome c reductase, cytochrome b5 and content or (ii) in vitro irreversible binding of 14CHCl3-derived radiolabel to microsomal protein. |
1(0,0,0,1) | Details |
| 6188242 | Chambers JE, Trevathan CA: Effect of mirex, dechlorinated mirex derivatives and chlordecone on microsomal mixed-function oxidase activity and other hepatic parameters. Toxicol Lett. 1983 Apr;16(1-2):109-15. All compounds increased microsomal cytochrome P-450 content, -cytochrome c reductase activity, and hepatic concentration. |
1(0,0,0,1) | Details |
| 76346 | Kaminsky LS, Piper LJ, McMartin DN, Fasco MJ: Induction of hepatic microsomal cytochrome P-450 by mirex and kepone. Toxicol Appl Pharmacol. 1978 Feb;43(2):327-38. |
1(0,0,0,1) | Details |
| 6200121 | Ebel RE: Hepatic microsomal p-nitroanisole O-demethylase. Biochem Pharmacol. 1984 Feb 15;33(4):559-64. Effects of chlordecone or mirex induction in male and female rats.. Both pesticides elevated the levels of cytochrome P-450 in a time- and dose-dependent manner. |
1(0,0,0,1) | Details |
| 8722114 | Hodgson E, Levi PE: Pesticides: an important but underused model for the environmental health sciences. Environ Health Perspect. 1996 Mar;104 Suppl 1:97-106. Aspects considered include the role of pesticides as substrates for xenobiotic-metabolizing enzymes such as cytochrome P450 and the flavin-containing monooxygenase and their role as inducers or inhibitors of metabolic enzymes. |
1(0,0,0,1) | Details |
| 6196592 | Klingensmith JS, Mehendale HM: Destruction of hepatic mixed-function oxygenase parameters by CCl4 in rats following acute treatment with chlordecone, Mirex, and phenobarbital. Life Sci. 1983 Dec 5;33(23):2339-48. M caused the least destruction of total hepatic cytochrome P-450, despite the same level of cytochrome P-450 as in the PB group. |
1(0,0,0,1) | Details |
| 2456051 | Bell AN, Young RA, Lockard VG, Mehendale HM: Protection of chlordecone-potentiated carbon tetrachloride hepatotoxicity and lethality by partial hepatectomy. Arch Toxicol. 1988 Apr;61(5):392-405. |
0(0,0,0,0) | Details |
| 7681558 | Cai Z, Mehendale HM: Resiliency to amplification of carbon tetrachloride hepatotoxicity by chlordecone during postnatal development in rats. Pediatr Res. 1993 Mar;33(3):225-32. |
0(0,0,0,0) | Details |
| 2469795 | Dolak JA, Britton RS, Glende EA Jr, Recknagel RO: Chlordecone does not interfere with hepatic repair after carbon tetrachloride or partial hepatectomy. J Biochem Toxicol. 1987 Spring;2:57-66. |
0(0,0,0,0) | Details |