| Name | ATPase |
|---|---|
| Synonyms | ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1… |
| Name | chlordecone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6196030 | Chetty SC, Aldous CN, Rashatwar SS, Desaiah D: Effect of chlordecone on pH and temperature dependent substrate activation kinetics of rat brain synaptosomal ATPases. Biochem Pharmacol. 1983 Nov 1;32(21):3205-11. Chlordecone, a polycyclic chlorinated insecticide known as Kepone, inhibited the activities of (Na+-K+) ATPase and Mg2+-ATPase in rat brain synaptosomes. |
250(3,3,4,5) | Details |
| 6160190 | Desaiah D: Comparative effects of chlordecone and mirex on rat cardiac ATPases and binding of 3H-catecholamines. J Environ Pathol Toxicol. 1980 Aug;4(1):237-48. The in vitro data showed that chlordecone significantly inhibited mitochondrial Mg2+ ATPase and Na+--K+ ATPase in a concentration dependent manner with ID50 values of 5 x 10 (-8) and 2 x 10 (-6) M, respectively. |
169(2,2,3,4) | Details |
| 2466998 | Curtis LR: Chlordecone is a potent in vitro inhibitor of oligomycin-insensitive Mg2+ -ATPase of rat bile canaliculi-enriched fraction. J Biochem Toxicol. 1988 Winter;3:321-8. |
163(2,2,2,3) | Details |
| 6158768 | Desaiah D, Gilliland T, Ho IK, Mehendale HM: Inhibition of mouse brain synaptosomal ATPases and ouabain binding by chlordecone. Toxicol Lett. 1980 Sep;6(4-5):275-85. The in vitro data show that chlordecone inhibits PNPPase, Na+-K+ ATPase, and Mg2+ ATPase activities with ID50 values of 4, 5 and 7 micrograms respectively. |
88(1,1,2,3) | Details |
| 2416942 | Desaiah D, Chetty CS, Rao KS: Chlordecone inhibition of calmodulin activated ATPase in rat brain synaptosomes. J Toxicol Environ Health. 1985;16(2):189-95. |
69(0,2,3,4) | Details |
| 2413407 | Bansal SK, Desaiah D: Chlordecone toxicity: effect of withdrawal of treatment on ATPase inhibition. Neurotoxicology. 1985 Fall;6(3):103-7. |
43(0,1,3,3) | Details |
| 2471839 | Jinna RR, Uzodinma JE, Desaiah D: Age-related changes in rat brain ATPases during treatment with chlordecone. J Toxicol Environ Health. 1989;27(2):199-208. These results suggest that the Na+ pump, Ca2+-ATPase, and ATP synthesizing enzymes are highly sensitive to chlordecone during early postnatal development. |
38(0,1,2,3) | Details |
| 1691869 | Maier WE, Costa LG: Na+/K (+)-ATPase in rat brain and erythrocytes as a possible target and marker, respectively, for neurotoxicity: studies with chlordecone, organotins and mercury compounds. Toxicol Lett. 1990 Apr;51(2):175-88. |
34(0,1,1,4) | Details |
| 6159026 | Mishra SK, Koury M, Desaiah D: Inhibition of ATPase activity in rat brain and muscle by chlordecone. Bull Environ Contam Toxicol. 1980 Aug;25(2):262-8. |
31(0,1,1,1) | Details |
| 6172757 | Jordan JE, Grice T, Mishra SK, Desaiah D: Acute chlordecone toxicity in rats: a relationship between tremor and ATPase activities. Neurotoxicology. 1981 Oct;2(2):355-64. |
14(0,0,2,4) | Details |
| 6175765 | Desaiah D: Interaction of chlordecone with biological membranes. . J Toxicol Environ Health. 1981 Nov-Dec;8(5-6):719-30. The order of sensitivity of the ATPases tested to chlordecone was: oligomycin-sensitive (mitochondrial) Mg2+-ATPase greater than Na+,K+-ATPase greater than Ca2+-ATPase greater than oligomycin-insensitive Mg2+-ATPase. |
13(0,0,2,3) | Details |
| 1717700 | Desaiah D, Pentyala SN, Trottman CH, Vig PJ, Sekhon BS: Combined effects of carbon tetrachloride and chlordecone on calmodulin activity in gerbil brain. J Toxicol Environ Health. 1991 Oct;34(2):219-28. Ca (2+)-ATPase and calmodulin (CaM) activities were determined in gerbil brain P2 fraction and cytosol, respectively, at intervals of 0.5, 2, 6, 12, and 24 h after CCl4 administration. |
4(0,0,0,4) | Details |
| 1701552 | Kodavanti PR, Cameron JA, Yallapragada PR, Desaiah D: Effect of chlordecone (Kepone) on transport mechanisms in rat heart sarcoplasmic reticulum. Pharmacol Toxicol. 1990 Sep;67(3):227-34. Cardiac SR Ca2 (+)-ATPase. 45Ca-uptake and cAMP as well as calmodulin (CaM) dependent protein phosphorylation were measured. |
3(0,0,0,3) | Details |
| 7690997 | Kodavanti PR, Rao VC, Mehendale HM: Loss of homeostasis leads to progressive phase of chlordecone-potentiated carbon tetrachloride hepatotoxicity. Toxicol Appl Pharmacol. 1993 Sep;122(1):77-87. Hepatic plasma membrane Ca (2+)-ATPase (high and low affinity components) as well as 45Ca uptake by mitochondria and microsomes was measured using a range of concentrations in Ca (2+)-EGTA-buffered medium at different time points after a single ip administration of CCl4 (100 microliters/kg). |
2(0,0,0,2) | Details |
| 1696822 | Kodavanti PR, Kodavanti UP, Mehendale HM: Altered hepatic energy status in chlordecone (Kepone)-potentiated CCl4 hepatotoxicity. Biochem Pharmacol. 1990 Aug 15;40(4):859-66. Oligomycin-sensitive Mg2 (+)-ATPase was decreased significantly only starting at 6 hr (21%) after CCl4 administration, indicating that depletion of ATP at early time points was most likely due to rapid utilization consequent to toxic events. |
2(0,0,0,2) | Details |
| 73494 | Koch RB, Desaiah D, Glick B, Subba Rao DS, Stinson R: Antibody reactivation of kepone inhibited brain ATPase activities. Gen Pharmacol. 1977;8(4):231-4. |
1(0,0,0,1) | Details |
| 66775 | Desaiah D, Ho IK, Mehendale HM: Effects of kepone and mirex on mitochondrial Mg2+-ATPase activity in rat liver. Toxicol Appl Pharmacol. 1977 Feb;39(2):219-28. |
1(0,0,0,1) | Details |
| 70207 | Desaiah D, Ho IK, Mehendale HM: Inhibition of mitochondrial Mg2+ ATPase activity in isolated perfused rat liver by kepone. Biochem Pharmacol. 1977 Jun 15;26(12):1155-9. |
1(0,0,0,1) | Details |
| 1696754 | Teo S, Vore M: Mirex exposure inhibits the uptake of -17 beta (beta-D- taurocholate, and into isolated rat hepatocytes. Toxicol Appl Pharmacol. 1990 Jul;104(3):411-20. The insecticides mirex and chlordecone have previously been found to suppress the biliary excretion of a wide variety of compounds. |
0(0,0,0,0) | Details |