| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | fenitrothion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12495187 | Rodriguez MM, Bisset J, Ruiz M, Soca A: Cross-resistance to pyrethroid and organophosphorus insecticides induced by selection with temephos in Aedes aegypti (Diptera: Culicidae) from Cuba. J Med Entomol. 2002 Nov;39(6):882-8. Little or no cross-resistance was observed to the organophosphates, malathion and fenitrothion, but high cross-resistance was observed for the pyrethroid deltamethrin (337.5x) and the organophosphate fenthion (12.74x). Synergism tests implicated detoxifying esterases in temephos and fenthion resistance and deltamethrin resistance was associated with a cytochrome P450 monooxygenasa. |
1(0,0,0,1) | Details |
| 7926597 | Clos MV, Ramoneda M, Garcia G: Modification of testicular cytochrome P-450 after fenitrothion administration. Gen Pharmacol. 1994 May;25(3):499-503. |
82(1,1,1,2) | Details |
| 9242588 | Berger CW Jr, Sultatos LG: The effects of the phosphorothioate insecticide fenitrothion on mammalian cytochrome P450-dependent metabolism of Fundam Appl Toxicol. 1997 Jun;37(2):150-7. |
31(0,1,1,1) | Details |
| 8511793 | Veronesi B, Ehrich M: Differential cytotoxic sensitivity in mouse and human cell lines exposed to organophosphate insecticides. Toxicol Appl Pharmacol. 1993 Jun;120(2):240-6. IC50 data indicated that the tested mouse cell line was consistently more sensitive than the human cell line to equimolar doses of various OP compounds (e.g., mipafox, parathion, paraoxon, DFP, leptophos oxon, fenthion, and fenitrothion). B-lymphoblastoids, genetically engineered with human P450 cDNAs, demonstrated higher cytotoxic sensitivity to parathion than unengineered cells, indicating that cytochrome P450-associated monooxidase activity could also influence cytotoxic sensitivity to parathion in culture. |
1(0,0,0,1) | Details |
| 8474020 | Verschoyle RD, Dinsdale D, Wolf CR: Inhibition and induction of cytochrome P450 isoenzymes in rat lung. . J Pharmacol Exp Ther. 1993 Apr;265(1):386-91. The O-dealkylation of pentoxyresorufin, a substrate for P450 2B1, was decreased in lung microsomes from rats dosed with O,O,S-trimethylphosphorodithioate, O,O,O-trimethylphosphorothioate, bromophos, fenitrothion, p-xylene and 2,4-dichloro-(6-phenylphonoxy) ethylamine. |
1(0,0,0,1) | Details |
| 11425027 | Lee SE, Lees EM: Biochemical mechanisms of resistance in strains of Oryzaephilus surinamensis (Coleoptera: Silvanidae) resistant to malathion and chlorpyrifos-methyl. J Econ Entomol. 2001 Jun;94(3):706-13. Cytochrome P450 monooxygenase activity was based on cytochrome P450 content, aldrin epoxidase activity, and oxidation of organophosphate insecticides, all elevated in resistant strains. |
1(0,0,0,1) | Details |
| 9972475 | Porte C, Escartin E: Cytochrome P450 system in the hepatopancreas of the red swamp crayfish Procambarus clarkii: a field study. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):333-8. Cytochrome P450 monooxygenase system and acetylcholinesterase (AChE) activity were studied in the red swamp crayfish Procambarus clarkii sampled from the Ebro Delta before and after spraying of the area with fenitrothion. |
1(0,0,0,1) | Details |
| 20183062 | Abass K, Turpeinen M, Pelkonen O: An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. J Environ Sci Health B. 2009 Aug;44(6):553-63. Generally organophosphorus insecticides were the most potent and extensive inhibitors, especially towards CYP1A1/2 (IC (50) values of chlorpyrifos, fenitrothion and profenofos approximately 3 micro M), CYP2B6 (IC (50) values of chlorpyrifos and fenitrothion 2.5 micro M), CYP2C8 (fenitrothion 4.3 micro M), CYP2C9 (fenitrothion and malathion 4.8 and 2.5 micro M, respectively), CYP2D6 (chlorpyrifos and phenthoate approximately 3 micro M) and CYP3A4 (chlorpyrifos, fenitrothion and phenthoate 3-4 micro M). |
1(0,0,0,1) | Details |