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fenitrothion

Identification (Source:EPA,EU)

ID	1548
Name	fenitrothion
CAS	122-14-5
IUPAC
Inchi	InChI=1S/C9H12NO5PS/c1-7-6-8(4-5-9(7)10(11)12)15-16(17,13-2)14-3/h4-6H,1-3H3
CIPAC	35
EPA Code	105901
Formula	C9H12NO5PS
SMILES	S=P(Oc1cc(c(cc1)[N+]([O-])=O)C)(OC)OC
Status	Not Approved

Classification

Mode of Action	Non-systemic, broad spectrum with contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
Pesticide Type	Insecticide
Chemical Group	Organophosphate
Classification	phenyl organothiophosphate insecticides organothiophosphate insecticides

Properties (Source:PubChem)

Molecular Weight	277.23
Physical State	Yellow brown liquid
AlogP	2.691
H-Bond Donor	0
H-Bond Acceptor	6
Surface Area	265.59
Polar Surface Area	115.41

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	1.3 mg l-1
Algae	Chronic	96 hour	NOEC, growth	0.1 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.000087 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.0086 mg l-1
Birds	Short term dietary		LC50/LD50	23 mg/kg bw/day
Birds	Acute		LD50	2.3 mg kg-1
Earthworms	Acute	14 day	LD50	231 mg kg-1
Earthworms	Chronic	14 day	NOEC, reproduction	25 mg kg-1
Fish	Chronic	21 day	NOEC	0.088 mg l-1
Fish	Acute	96 hour	LC50	1.3 mg l-1
Honeybees	Acute	48 hour	LD50	0.16 μg bee-1
Mammals	Acute oral		LD50	330 mg kg-1
Mammals	Short term dietary		NOEL	> 10 ppm diet
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	0.0017 mg kg-1
	Bio-concentration factor		CT50	0.19 days
	Bio-concentration factor		BCF	29

Related targets

Target Name	RScore (About this table)
Acetylcholinesterase	1610(10,26,56,180)	Details
cholinesterase	899(6,13,34,104)	Details
androgen receptor	192(1,4,6,12)	Details
cytochrome P450 (protein family or complex)	119(1,2,2,9)	Details
hemoglobins (protein family or complex)	119(1,1,6,14)	Details
C18	96(1,1,2,11)	Details
lactate dehydrogenase (protein family or complex)	88(1,1,1,8)	Details
DTNB	88(1,1,2,3)	Details
Dragon	87(1,1,2,2)	Details
SRBC	87(1,1,2,2)	Details
alanine aminotransferase	85(1,1,1,5)	Details
alkaline phosphatases	81(1,1,1,1)	Details
interleukin 1	81(1,1,1,1)	Details
ribonucleotide reductase (protein family or complex)	81(1,1,1,1)	Details
neurotoxic esterase	52(0,1,4,7)	Details
ATPase	45(0,1,3,5)	Details
MN1	39(0,1,2,4)	Details
brains	38(0,1,2,3)	Details
microsomal monooxygenases	37(0,1,2,2)	Details
multidrug resistance associated protein 1	34(0,1,1,4)	Details
CYP2D6	33(0,1,1,3)	Details
CYP3A4	33(0,1,1,3)	Details
glutathione transferase	32(0,1,1,2)	Details
CYP2C9	32(0,1,1,2)	Details
CYP1A1	32(0,1,1,2)	Details
CYP2B6	31(0,1,1,1)	Details
glutathione S transferase	24(0,0,2,14)	Details
glutamyl transpeptidase	22(0,0,3,7)	Details

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