| Name | androgen receptor |
|---|---|
| Synonyms | AIS; AR; Androgen receptor; DHTR; Dihydrotestosterone receptor; HUMARA; KD; NR3C4… |
| Name | fenitrothion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11404828 | Sohoni P, Lefevre PA, Ashby J, Sumpter JP: Possible androgenic/anti-androgenic activity of the insecticide fenitrothion. J Appl Toxicol. 2001 May-Jun;21(3):173-8. Using recombinant yeast expressing the human androgen receptor, we found that fenitrothion behaved as an androgen agonist in vitro when tested alone, and that it could antagonize the androgen DHT when both chemicals competed for the androgen receptor in vitro. |
82(1,1,1,2) | Details |
| 11222873 | Tamura H, Maness SC, Reischmann K, Dorman DC, Gray LE, Gaido KW: Androgen receptor antagonism by the organophosphate insecticide fenitrothion. Toxicol Sci. 2001 Mar;60(1):56-62. We investigated the interaction of the organophosphothioate pesticide fenitrothion (O,O-dimethyl O-(4-nitro-m-tolyl) phosphorothioate) with the human androgen receptor (AR). |
37(0,1,2,2) | Details |
| 17582585 | Struve MF, Turner KJ, Dorman DC: Preliminary investigation of changes in the sexually dimorphic nucleus of the rat medial preoptic area following prenatal exposure to fenitrothion. J Appl Toxicol. 2007 Nov-Dec;27(6):631-6. In vitro, the organophosphate insecticide fenitrothion is a potent competitive androgen receptor antagonist, whereas in vivo it affects the development of the male rat reproductive system. |
31(0,1,1,1) | Details |
| 12075120 | Turner KJ, Barlow NJ, Struve MF, Wallace DG, Gaido KW, Dorman DC, Foster PM: Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD (SD) BR rat. Toxicol Sci. 2002 Jul;68(1):174-83. At the dose levels evaluated in this study, fenitrothion was only weakly antiandrogenic in vivo compared with other androgen receptor antagonists such as flutamide, linuron, and vinclozolin. |
31(0,1,1,1) | Details |
| 11399807 | Goodman JI: Re: androgen receptor antagonism by the organophosphate insecticide fenitrothion. Toxicol Sci. 2001 Jul;62(1):183. |
6(0,0,1,1) | Details |
| 12676613 | Tamura H, Yoshikawa H, Gaido KW, Ross SM, DeLisle RK, Welsh WJ, Richard AM: Interaction of organophosphate pesticides and related compounds with the androgen receptor. Environ Health Perspect. 2003 Apr;111(4):545-52. We previously demonstrated AR antagonist activity of the organophosphate (OP) pesticide fenitrothion. |
2(0,0,0,2) | Details |
| 11222865 | Curtis LR: Organophosphate antagonism of the androgen receptor. Toxicol Sci. 2001 Mar;60(1):1-2. |
1(0,0,0,1) | Details |
| 11201171 | Sunami O, Kunimatsu T, Yamada T, Yabushita S, Sukata T, Miyata K, Kamita Y, Okuno Y, Seki T, Nakatsuka I, Matsuo M: Evaluation of a 5-day Hershberger assay using young mature male rats: methyltestosterone and p,p'-DDE, but not fenitrothion, exhibited androgenic or antiandrogenic activity in vivo. J Toxicol Sci. 2000 Dec;25(5):403-15. A 5-day Hershberger assay using young mature male rats to detect compounds interfering with androgen receptor (AR)-mediated mechanisms was evaluated for ability to identify p,p'-DDE (a weak AR antagonist) and methyltestosterone (MT, an AR agonist). |
1(0,0,0,1) | Details |
| 15253041 | Okubo T, Yokoyama Y, Kano K, Soya Y, Kano I: Estimation of estrogenic and antiestrogenic activities of selected pesticides by MCF-7 cell proliferation assay. Arch Environ Contam Toxicol. 2004 May;46(4):445-53. Antiestrogenic activities of nitrofen, fenitrothion, fenarimol and triadimefon were also suggested. Affinities of the compounds for ERalpha and/or androgen receptor (AR) were lower than those of synthetic (diethylstilbestrol) and (mibolerone), respectively. |
1(0,0,0,1) | Details |