| Name | ceruloplasmin |
|---|---|
| Synonyms | CP; CP protein; Ceruloplasmin; Ceruloplasmin precursor; Ferroxidase; ceruloplasmin (ferroxidase); CP; CP proteins… |
| Name | copper sulfate |
|---|---|
| CAS | sulfuric acid copper(2+) salt (1:1) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7823395 | Banno S, Niita M, Kikuchi M, Wakita A, Takada K, Mitomo Y, Niimi T, Yamamoto T: [Anemia and neutropenia in elderly patients caused by copper deficiency for long-term enteral nutrition]. Rinsho Ketsueki. 1994 Nov;35(11):1276-81. We present 6 bed-ridden elderly patients who developed anemia and neutropenia after receiving enteral nutrition for a long time (mean: 3.3 years) In all 6 patients, serum and ceruloplasmin level were very low, and the mean of their hematological data were as follows: WBC 2,200/microliters, neutrophil 554/microliters, hemoglobin 8.1 g/dl, platelet 260 x 10 (3)/microliters, respectively. Then, copper sulfate was administrated by enteral tube to 6 patients, and the improvement of anemia and neutropenia was observed within a month. |
1(0,0,0,1) | Details |
| 19033537 | Braiterman L, Nyasae L, Guo Y, Bustos R, Lutsenko S, Hubbard A: Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the -ATPase, ATP7B. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G433-44. Epub 2008 Nov 25. In basal hepatic ATP7B is in a post-trans-Golgi network (TGN) compartment where it loads cytoplasmic Cu (I) onto newly synthesized ceruloplasmin. |
1(0,0,0,1) | Details |
| 20190976 | Zhou L, Long R, Pu X, Qi J, Zhang W: Studies of a naturally occurring -induced copper deficiency in Przewalski's gazelles. Can Vet J. 2009 Dec;50(12):1269-72. Affected Przewalski's gazelles showed a hypochromic microcytic anemia and a low level of ceruloplasmin. |
1(0,0,0,1) | Details |
| 12741549 | Scaletti RW, Trammell DS, Smith BA, Harmon RJ: Role of dietary in enhancing resistance to Escherichia coli mastitis. J Dairy Sci. 2003 Apr;86(4):1240-9. Twenty-three primigravid Holstein heifers were maintained on a basal (6.5 ppm -Cu) diet or a diet supplemented (20 ppm) with copper sulfate (+Cu) beginning 60 d prepartum through 42 d of lactation. Liver biopsies and blood samples were taken for liver and blood minerals and plasma ceruloplasmin. |
1(0,0,0,1) | Details |
| 3934352 | Uauy R, Castillo-Duran C, Fisberg M, Fernandez N, Valenzuela A: Red cell superoxide dismutase activity as an index of human nutrition. J Nutr. 1985 Dec;115(12):1650-5. Nine served as controls receiving a copper sulfate supplement (80 micrograms/kg daily for 120 d; eight received a placebo and were supplemented only if plasma levels dropped below 90 micrograms/dl or on d 90 for at least 30 d. After supplementation there was a significant rise (paired t-test; P less than 0.05) in plasma (96 vs. 165 micrograms/dl); ceruloplasmin (33 vs. 50 mg/dl) and SOD (1073 vs. 1371 U/g Hb). |
1(0,0,0,1) | Details |
| 304669 | Zidar BL, Shadduck RK, Zeigler Z, Winkelstein A: Observations on the anemia and neutropenia of human copper deficiency. . Am J Hematol. 1977;3:177-85. This consisted of hypocupremia, subnormal ceruloplasmin levels, anemia, and severe neutropenia. Copper sulfate therapy was followed by a marked reticulocytosis, increase in hematocrit, and recovery of neutrophils. |
1(0,0,0,1) | Details |
| 7831754 | Liu ZP, Ma Z, Zhang YJ: Studies on the relationship between sway disease of bactrian camels and status in Gansu province. Vet Res Commun. 1994;18(4):251-60. There was a hypochromic microcytic anaemia and a low level of ceruloplasmin in the blood. |
1(0,0,0,1) | Details |
| 11673125 | Pizarro F, Olivares M, Araya M, Gidi V, Uauy R: Gastrointestinal effects associated with soluble and insoluble in drinking water. Environ Health Perspect. 2001 Sep;109(9):949-52. Forty-five healthy adult women (18-55 years of age), living in Santiago, Chile, ingested tap water with 5 mg/L of containing different ratios of soluble (copper sulfate) and insoluble oxide) over a 9-week period. Serum levels, ceruloplasmin, and activities of liver enzymes were within normal limits. |
1(0,0,0,1) | Details |
| 8492415 | Takeuchi M, Tada A, Yoshimoto S, Takahashi K: [Anemia and neutropenia due to copper deficiency during long-term total parenteral nutrition]. Rinsho Ketsueki. 1993 Feb;34(2):171-6. Both serum and ceruloplasmin were very low (12 micrograms/dl and 7mg/dl, respectively). Thus, oral administration of copper sulfate resulted in marked increase of reticulocytes and subsequent improvement of anemia and neutropenia within two months. |
1(0,0,0,1) | Details |
| 12512603 | Yost GP, Arthington JD, McDowell LR, Martin FG, Wilkinson NS, Swenson CK: Effect of source and level on the rate and extent of repletion in Holstein heifers. J Dairy Sci. 2002 Dec;85(12):3297-303. Plasma ceruloplasmin concentration was higher (P < 0.001) in IB-treated heifers vs. other treatments. |
1(0,0,0,1) | Details |
| 12477272 | Chirico G, Motta M, Villani P, Cavazza A, Cardone ML: Late-onset neutropenia in very low birthweight infants. Acta Paediatr Suppl. 2002;91(438):104-8. Oral copper sulfate was administered to infants with plasma concentration <50 microg dl (-1), and did not seem to affect ANC, hemoglobin, hematocrit or reticulocyte counts. In neutropenic infants plasma and ceruloplasmin levels were also measured. |
1(0,0,0,1) | Details |
| 16847394 | Kawada E, Moridaira K, Itoh K, Hoshino A, Tamura J, Morita T: In long-term bedridden elderly patients with dietary copper deficiency, biochemical markers of bone resorption are increased with supplementation during 12 weeks. Ann Nutr Metab. 2006;50(5):420-4. Epub 2006 Jul 17. They had their diets supplemented with copper sulfate (3 mg/day) over 12 weeks in addition to their diet of only one kind of enteral food with a low concentration of Serum and ceruloplasmin, urinary (DPD) and collagen-type 1 N-telopeptide (NTX) (biomarkers of bone resorption), serum osteocalcin (OC) and bone-specific alkaline phosphatase (Bone ALP) (biomarkers of bone formation) were analyzed at baseline, 4 and 12 weeks after supplementation. |
1(0,0,0,1) | Details |
| 19685012 | Arredondo M, Nunez H, Lopez G, Pizarro F, Ayala M, Araya M: Influence of Estrogens on Indicators: In Vivo and In Vitro Studies. Biol Trace Elem Res. 2009 Aug 14. Serum and ceruloplasmin (Cp) are the most commonly used indicators to assess nutritional status of Participants received 8 mg Cu/day (as copper sulfate) during 6 months. |
1(0,0,0,1) | Details |
| 10629812 | Rabiansky PA, McDowell LR, Velasquez-Pereira J, Wilkinson NS, Percival SS, Martin FG, Bates DB, Johnson AB, Batra TR, Salgado-Madriz E: Evaluating and copper sulfate sources for heifers. J Dairy Sci. 1999 Dec;82(12):2642-50. In addition to performance, concentrations of Cu, Fe, and Zn in the plasma and liver, plasma ceruloplasmin, hemoglobin, superoxide dismutase (SOD) activity of neutrophils and lymphocytes, and a cell mediated immune response (phytohemagglutinin-P, PHA) were measured. |
1(0,0,0,1) | Details |
| 4026887 | Staite ND, Messner RP, Zoschke DC: In vitro production and scavenging of peroxide by D-penicillamine. Arthritis Rheum. 1985 Aug;28(8):914-21. Greater production was observed with copper sulfate than with bound to ceruloplasmin. |
81(1,1,1,1) | Details |
| 7990697 | Buchman AL, Keen CL, Vinters HV, Harris E, Chugani HT, Bateman B, Rodgerson D, Vargas J, Verity A, Ament M: Copper deficiency secondary to a transport defect: a new metabolic disturbance. Metabolism. 1994 Dec;43(12):1462-9. His serum was low and did not increase despite administration of large doses of intravenous copper sulfate. The ceruloplasmin level as measured by an antibody technique was normal, yet ceruloplasmin (Cp) oxidase activity was very low. |
1(0,0,0,1) | Details |
| 11849228 | Peled T, Landau E, Prus E, Treves AJ, Nagler A, Fibach E: Cellular content modulates differentiation and self-renewal in cultures of cord blood-derived CD34+ cells. Br J Haematol. 2002 Mar;116(3):655-61. Modulation of intracellular Cu was achieved by supplementing the cultures with the Cu chelator tetraethylenepentamine, which reduced cellular Cu (4 ng/10 (7) cells), or ceruloplasmin or Cu sulphate that elevated cellular Cu (18 and 14 ng/10 (7) cells respectively). |
1(0,0,0,1) | Details |
| 3514679 | Starkebaum G, Harlan JM: Endothelial cell injury due to -catalyzed peroxide generation from J Clin Invest. 1986 Apr;77(4):1370-6. Ceruloplasmin was also found to catalyze oxidation of and generation of H2O2 in molar amounts equivalent to copper sulfate. |
32(0,1,1,2) | Details |
| 7883634 | Kegley EB, Spears JW: Bioavailability of feed-grade sources (oxide, or in growing cattle. J Anim Sci. 1994 Oct;72(10):2728-34. Plasma Cu concentrations and ceruloplasmin (a Cu metalloenzyme) activity were used to assess relative Cu bioavailability from different Cu sources for growing cattle. |
5(0,0,0,5) | Details |
| 10801931 | Fascetti AJ, Rogers QR, Morris JG: Dietary influences reproduction in cats. J Nutr. 2000 May;130(5):1287-90. Specific pathogen-free queens (n = 28) were adapted to a purified diet; after consuming a -depletion diet (0.8 mg Cu/kg diet) for 4 mo, they were randomly allocated to three dietary treatment groups receiving copper sulfate at 4.0, 5.8 or 10.8 mg Cu/kg diet. Plasma samples were analyzed for concentrations, extracellular superoxide dismutase, ceruloplasmin and diamine oxidase activities. |
1(0,0,0,1) | Details |
| 17701079 | Sharma MC, Joshi C, Das G: Therapeutic management of copper deficiency in buffalo heifers: impact on immune function. Vet Res Commun. 2008 Jan;32(1):49-63. Epub 2007 Aug 14. Significant (p <0.01) improvement in serum ceruloplasmin level was observed within 30 days of treatment, while significant (p <0.01) improvement in monoamine oxidase and liver cytochrome oxidase was observed at the 60th day of treatment in group A animals. |
1(0,0,0,1) | Details |
| 17911232 | Hansen SL, Schlegel P, Legleiter LR, Lloyd KE, Spears JW: Bioavailability of from glycinate in steers fed high dietary and J Anim Sci. 2008 Jan;86(1):173-9. Epub 2007 Oct 2. Sixty Angus (n = 29) and Angus-Sim-mental cross (n = 31) steers, averaging 9 mo of age and 277 kg of initial BW, were used in a 148-d study to determine the bioavailability of glycinate (CuGly) relative to feed-grade copper sulfate (CuSO (4)) when supplemented to diets high in S and Mo. Final ceruloplasmin, plasma Cu, and liver Cu values were greater (P < 0.05) in steers fed supplemental Cu compared with controls. |
4(0,0,0,4) | Details |
| 8805205 | Koh TS, Peng RK, Klasing KC: Dietary level affects metabolism during lipopolysaccharide-induced immunological stress in chicks. Poult Sci. 1996 Jul;75(7):867-72. Ceruloplasmin levels were higher in chicks challenged with LPS than in control chicks (P = 0.03), and this difference tended to be greater in chickens fed CuO than in chickens fed CuSO4 (P = 0.07). |
4(0,0,0,4) | Details |
| 17017658 | Shen XY, Du GZ, Chen YM, Fan BL: Copper deficiency in yaks on pasture in western China. Can Vet J. 2006 Sep;47(9):902-6. Affected yaks showed a hypochromic microcytic anemia and a low level of ceruloplasmin. |
1(0,0,0,1) | Details |
| 15924928 | Sharma MC, Joshi C, Pathak NN, Kaur H: status and enzyme, hormone, vitamin and immune function in heifers. Res Vet Sci. 2005 Oct;79(2):113-23. Epub 2005 Mar 4. Ceruloplasmin (Cp) level was observed within 30 days of treatment, while significant (P <0.01) improvement in monoamine oxidase and liver cytochrome oxidase was observed at the 60th day of treatment in group A animals. |
1(0,0,0,1) | Details |
| 18185996 | Ayala M, Pizarro F, Mendez MA, Arredondo M, Araya M: and liver function indicators vary depending on the female hormonal cycle and serum hormone binding globulin (SHBG) concentration in healthy women. Biol Trace Elem Res. 2008 Jan;121(1):9-15. Epub 2007 Oct 9. Healthy females on day 7 (follicular phase, Group 1, n = 39), on day 21 (secretory phase, Group 2, n = 34) and males (comparison group, Group 3, n = 34) received 8 mg Cu/day (as copper sulfate), orally, for 6 months. On days 0, 30, 60, 120, and 180, the serum concentration of ceruloplasmin, liver aminotransferases, and SHBG were measured. |
3(0,0,0,3) | Details |
| 12597403 | Mullis LA, Spears JW, McCraw BL: Effects of breed (Angus vs Simmental) and and zinc source on mineral status of steers fed high dietary iron. J Anim Sci. 2003 Jan;81(1):318-22. Serum samples were collected initially and at 28-d intervals for determination of ceruloplasmin activity and Zn and Cu concentrations. |
2(0,0,0,2) | Details |
| 7279467 | Naveh Y, Hazani A, Berant M: Copper deficiency with cow's milk diet. Pediatrics. 1981 Sep;68(3):397-400. Thorough investigation revealed low serum iron concentration, severe hypocupremia, low ceruloplasmin, retardation of bone age, and metaphysial irregularities and spurring. Administration of copper sulfate resulted in brisk increase in neutrophils and reticulocytes. |
2(0,0,0,2) | Details |
| 9924006 | Pizarro F, Olivares M, Uauy R, Contreras P, Rebelo A, Gidi V: Acute gastrointestinal effects of graded levels of in drinking water. Environ Health Perspect. 1999 Feb;107(2):117-21. Each group (n = 15) received tap water with no added 1, 3, and 5 mg Cu/l of added copper sulfate for a 2-week study period, followed by 1 week of standard tap water. |
0(0,0,0,0) | Details |
| 17060415 | Arthington JD, Spears JW: Effects of tribasic versus copper sulfate provided in corn-and molasses-based supplements on forage intake and status of beef heifers. J Anim Sci. 2007 Mar;85(3):871-6. Epub 2006 Oct 23. |
0(0,0,0,0) | Details |
| 6131953 | Hill GM, Ku PK, Miller ER, Ullrey DE, Losty TA, O'Dell BL: A copper deficiency in neonatal pigs induced by a high zinc maternal diet. J Nutr. 1983 Apr;113(4):867-72. The dietary treatments were 0, 5 and 10 ppm added from copper sulfate. |
0(0,0,0,0) | Details |
| 8923258 | Du Z, Hemken RW, Harmon RJ: metabolism of holstein and jersey cows and heifers fed diets high in cupric or proteinate. J Dairy Sci. 1996 Oct;79(10):1873-80. Overall, serum ceruloplasmin oxidase activity was greater for Jerseys than for Holsteins. |
2(0,0,0,2) | Details |
| 17916969 | Feng J, Ma WQ, Gu ZL, Wang YZ, Liu JX: Effects of dietary (II) and proteinate on performance and blood indexes of status in growing pigs. Biol Trace Elem Res. 2007 Winter;120(1-3):171-8. 160 crossbred (Duroc x Landrace x Yorkshire) gilts averaged 21.25 kg body weight were used to study the effects of dietary (II) (CuSO4) and proteinate (Cu-Pr) on growth performance, plasma Cu concentration, ceruloplasmin activity, and erythrocyte Cu/Zn-superoxide dismutase (SOD) activity. |
2(0,0,0,2) | Details |
| 17575443 | Kawada E, Moridaira K, Sato H, Ukita T, Itoh K, Tatsumi T, Kogure T, Tamura J, Sakamoto H: [Effects of supplementation on lipid profiles in elderly patients with copper deficiency]. Nippon Ronen Igakkai Zasshi. 2007 May;44(3):375-9. METHODS: Nine long-term bed-ridden, patients (5 men and 4 women, mean age 83.3+/-8.7 years old) with severe copper deficiency, who had a serum of 15 microg/dL or less (normal range 70-140 microg/dL), had their diets supplemented with copper sulfate (3 mg/day) over 12 weeks in addition to their diet of only one kind of enteral food with a low concentration of ceruloplasmin, total (TC), triacylglycerides (TG), HDL- (HDL-C), c-reactive protein (CRP), (Cr), zinc (Zn) and albumin (Alb) in the serum were measured before, 4 weeks and 12 weeks after supplementation. |
2(0,0,0,2) | Details |
| 17575375 | Chen CC, Takeshima F, Miyazaki T, Murase K, Ohtani H, Isomoto H, Shikuwa S, Omagari K, Mizuta Y, Ozono Y, Kohno S: Clinicopathological analysis of hematological disorders in tube-fed patients with copper deficiency. Intern Med. 2007;46(12):839-44. Epub 2007 Jun 15. PATIENTS AND METHODS: Serum samples were obtained from 15 bed-ridden elderly patients receiving tube feeding (TF) and 10 age-matched bed-ridden patients who took food orally (CO), and the ceruloplasmin concentration of each sample was measured. Copper sulfate was administered to those 7 patients by enteral tube; their concentration, anemia and leukopenia improved within 1 month after they were administered copper sulfate. |
2(0,0,0,2) | Details |
| 6117609 | Disilvestro RA, Harris ED: A postabsorption effect of on metabolism in chicks. J Nutr. 1981 Nov;111(11):1964-8. When the was given to chicks that had received adequate dietary there was a strong rise in ceruloplasmin and a slight, but significant increase in lysyl oxidase. |
2(0,0,0,2) | Details |
| 10528324 | Guitet M, Campistol J, Medina M: [Menkes disease: experience in salts therapy] . Rev Neurol. 1999 Jul 16-31;29(2):127-30. On the basis of and ceruloplasmin plasma levels, doses of treatment were controlled until a maintained dose of 1,000 micrograms intramuscular of sulphate every 17 days, until the age of 6 years. |
1(0,0,0,1) | Details |
| 2975107 | Lipsky PE: Suggested mode of action of D-penicillamine as an immunosuppressive agent in rheumatoid arthritis. Z Rheumatol. 1988;47 Suppl 1:6-8. The results indicate that D-Penicillamine in synergism with or ceruloplasmin in vitro inhibits the proliferation of T-lymphocytes and the activity of helper T-cells in supporting the generation of antibody-forming cells. |
1(0,0,0,1) | Details |
| 6405558 | Kirchgessner M, Kim JJ, Grassmann E: [Cu and Fe content and ceruloplasmin and catalase activities in the blood of growing rats receiving different amounts of Fe and Cu] Zentralbl Veterinarmed A. 1983 Jan;30(1):15-25. |
1(0,0,0,1) | Details |
| 12899943 | Santamaria A, Flores-Escartin A, Martinez JC, Osorio L, Galvan-Arzate S, Pedraza-Chaverri J, Maldonado PD, Medina-Campos ON, Jimenez-Capdeville ME, Manjarrez J, Rios C: blocks neurotoxicity in rats: contribution of antioxidant systems. Free Radic Biol Med. 2003 Aug 15;35(4):418-27. In addition, reduced the QUIN-induced decreased striatal activity of Cu,Zn-dependent superoxide dismutase, and increased the ferroxidase activity of ceruloplasmin in cerebrospinal fluid from QUIN-treated rats. |
1(0,0,0,1) | Details |
| 7293527 | Grassmann E, Kirchgessner M, Mader H: [Cu and Fe metabolism of baby pigs with different supply following injections of Cu- ceruloplasmin and Fe- Z Tierphysiol Tierernahr Futtermittelkd. 1981;46(3):132-8. |
1(0,0,0,1) | Details |
| 10375726 | Aaseth J, Korkina LG, Afanas'ev IB: Hemolytic activity of copper sulfate as influenced by and chelating thiols. Zhongguo Yao Li Xue Bao. 1998 May;19(3):203-6. The plasma protein ceruloplasmin reduced markedly the --induced hemolysis, even upon concentrations < 20% of that of |
1(0,0,0,1) | Details |
| 10064051 | Eckert GE, Greene LW, Carstens GE, Ramsey WS: status of ewes fed increasing amounts of from copper sulfate or proteinate. J Anim Sci. 1999 Jan;77(1):244-9. On d 73, plasma ceruloplasmin activity was greater (P <.05) in ewes fed Cu proteinate than in those fed CuSO4 (33.1 vs. 26.8 microM x min (-1) x L (-1)). |
1(0,0,0,1) | Details |
| 10338225 | Spiegel JE, Willenbucher RF: Rapid development of severe copper deficiency in a patient with Crohn's disease receiving parenteral nutrition. JPEN J Parenter Enteral Nutr. 1999 May-Jun;23(3):169-72. Although serum ceruloplasmin levels were within normal limits, 8 weeks after removal, he developed pancytopenia. IV replacement with copper sulfate resulted in improvement in the patient's anemia, neutropenia, and thrombocytopenia, but the patient died suddenly from cardiac tamponade. |
1(0,0,0,1) | Details |