| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | azobenzene |
|---|---|
| CAS | diphenyldiazene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1912304 | Zbaida S, Levine WG: A novel application of cyclic voltammetry for direct investigation of metabolic intermediates in microsomal azo reduction. Chem Res Toxicol. 1991 Jan-Feb;4(1):82-8. We have established that reduction of azo dyes structurally related to 4-(dimethylamino)-azobenzene (DAB) by rat liver microsomal cytochrome P-450 requires a polar electron-donating substituent on one ring. |
31(0,1,1,1) | Details |
| 3312182 | Degawa M, Yamada H, Hishinuma T, Masuko T, Hashimoto Y: Organ selective induction of cytochrome P-448 isozymes in the rat by 2-methoxy-4-aminoazobenzene and 3-methylcholanthrene. J Biochem. 1987 Jun;101(6):1437-45. Male Sprague Dawley rats were injected intraperitoneally with 2-methoxy-4-amino-azobenzene (2-MeO-AAB) or 3-methylcholanthrene (MC), and then the expression of microsomal cytochrome P-450 isozymes in liver and extrahepatic tissues was investigated by means of immunological methods and a bacterial mutation test. |
6(0,0,1,1) | Details |
| 8521752 | Zbaida S: The mechanism of microsomal azoreduction: predictions based on electronic aspects of structure-activity relationships. Drug Metab Rev. 1995;27(3):497-516. Anaerobic cyclic voltammograms of azobenzene derivatives verify the following points: A nonsubstrate azo dye will not exhibit a positive potential. (Several nonsubstrate hydrazobenzenes exhibited positive potentials, but in a low range 0.41-0.48 V. A comparison between the oxidative and the reductive pathway of microsomal cytochrome P450 indicates a similarity in the first two steps in the reaction cycle, for example, substrate binding and uptake of the first electron by the cytochrome [76, 109, 110]. |
4(0,0,0,4) | Details |
| 2914330 | Zbaida S, Stoddart AM, Levine WG: Studies on the mechanism of reduction of azo dye carcinogens by rat liver microsomal cytochrome P-450. Chem Biol Interact. 1989;69(1):61-71. In contrast, only negligible rates were obtained for unsubstituted azobenzene (1g), hydrazobenzene (2g), p-isopropylazobenzene (1e) and 1f, the benzoylamide derivative of 1b. |
3(0,0,0,3) | Details |
| 2788017 | Precious WY, Barrett J: The possible absence of cytochrome P-450 linked xenobiotic metabolism in helminths. Biochim Biophys Acta. 1989 Aug 18;992(2):215-22. P. redivivus was able to reduce 1,2-dimethyl-4-(4-carboxyphenylazo)-5- and azobenzene, which is predominantly microsomal. |
2(0,0,0,2) | Details |
| 6413856 | Mori Y, Niwa T, Toyoshi K: Participation of cytochrome P450 in mutagenic activation of the carcinogen 3'-hydroxymethyl-N,N-dimethyl-4-aminoazobenzene and its N-demethylated compounds by rat liver. Mutat Res. 1983 Oct;122(1):13-22. |
1(0,0,0,1) | Details |
| 6807533 | Hino O, Nemoto N, Nagao M, Kosugi A, Kitagawa T: Induction of drug-metabolizing enzymes in the rat liver by 3'-methyl-4-(dimethylamino) azobenzene. Cancer Lett. 1982 Feb;15(2):131-6. Feeding of 3-Me-DAB for 3 weeks at 10, 20 and 600 ppm increased the content of hepatic microsomal cytochrome P-450 slightly (up to 27% raise) but significantly. |
1(0,0,0,1) | Details |
| 102518 | Danz M, Klinger W, Muller D, Kleeberg U, Glockner R, Ziebarth D, Urban H: N,N-diethyl-4-aminoazobenzene (DEAB): acute actions with respect to possible carcinogenicity as well as the role of solvents. Exp Pathol. 1978;16(1-6):245-53. Cytochrome P-450-DEPENDENT N-demethylation of ethylmorphine and dimethylnitrosamine are differentially altered depending on the solvent used. The excretion of DEAB as well as of N,N-dimethyl-4-amino-azobenzene (DAB) is delayed and diminished if the substances are dissolved in DMSO. |
1(0,0,0,1) | Details |
| 1970775 | Stoddart AM, Levine WG: Azoreduction of dimethylaminoazobenzene (DAB) in primary cultures of rat hepatocytes. Drug Metab Dispos. 1990 Jan-Feb;18(1):36-41. This laboratory has investigated the azoreduction of the hepatocarcinogen, N,N-dimethyl-4-aminoazobenzene (DAB), by hepatic microsomal cytochrome P-450 (P-450) and its specific induction by the hypolipidemic drug, clofibrate. |
1(0,0,0,1) | Details |
| 11338675 | Muhlenfeld K, Langner A: Cytochrome P450 1A1 and 4A activities in isolated rat spleen lymphocytes. . Pharmazie. 2001 Apr;56(4):329-31. In this study the activity of Cytochrome P 450 (CYP) enzymes in isolated spleen lymphocytes of Wistar rats was estimated. 7-Ethoxyresorufin-O-deethylase was analysed to determine the activity of CYP 1A1/2. To estimate reductive activities the azoreduction of 4-(N,N-dimethyl-amino) azobenzene was analysed. |
1(0,0,0,1) | Details |
| 3929790 | Levine WG: Studies on microsomal azoreduction. Biochem Pharmacol. 1985 Sep 15;34(18):3259-64. These findings suggest that microsomal azoreduction of DAB and MAB may proceed via different mechanisms, possibly through different species of cytochrome P-450 which have selective dependence upon the sulfhydryl environment. The azoreduction of N,N-dimethyl-4-aminoazobenzene (DAB) and N-methyl-4-amino-azobenzene (MAB) by rat liver microsomes was investigated. |
1(0,0,0,1) | Details |