| Name | acetylcholine receptor (protein family or complex) |
|---|---|
| Synonyms | Acetylcholine receptor; Acetylcholine receptors |
| Name | azobenzene |
|---|---|
| CAS | diphenyldiazene |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2423118 | Delcour AH, Hess GP: Chemical kinetic measurements of the effect of trans- and cis-3,3'-Bis [(trimethylammonio) methyl] azobenzene on acetylcholine receptor mediated ion translocation in Electrophorus electricus and Torpedo californica. Biochemistry. 1986 Apr 8;25(7):1793-8. A quench-flow technique was used to study the effect of trans- and cis-3,3'-bis [(trimethylammonio) methyl] azobenzene (trans- and cis-Bis-Q), photoisomerizable ligands, on the acetylcholine receptor in vesicles prepared from the electric organ of Electrophorus electricus and of Torpedo californica. |
112(1,2,2,2) | Details |
| 6181515 | Wassermann NH, Penn AS, Freimuth PI, Treptow N, Wentzel S, Cleveland WL, Erlanger BF: Anti-idiotypic route to anti-acetylcholine receptor antibodies and experimental myasthenia gravis. Proc Natl Acad Sci U S A. 1982 Aug;79(15):4810-4. trans-3,3'-Bis [alpha-(trimethylammonio) methyl] azobenzene (BisQ) is a potent agonist of the acetylcholine receptor (AcChoR) of Electrophorus electricus. |
82(1,1,1,2) | Details |
| 4525321 | Chang HW: Purification and characterization of acetylcholine receptor-I from Electrophorus electricus. Proc Natl Acad Sci U S A. 1974 May;71(5):2113-7. Specific elution of the acetylcholine receptor-I (AcChR-I) with low concentration of a bis-quaternary agonist, 3,3'-bis [alpha-(trimethylammonium) methyl]-azobenzene (Bis-Q), gave a 35% yield of toxin-binding components in the crude extract. |
32(0,1,1,2) | Details |
| 284340 | Wassermann NH, Bartels E, Erlanger BF: Conformational properties of the acetylcholine receptor as revealed by studies with constrained depolarizing ligands. Proc Natl Acad Sci U S A. 1979 Jan;76(1):256-9. Among the compounds synthesized was 3,3'-bis [alpha-(trimethylammonium)-methyl] azobenzene dibromide (3,3'-bisQ). |
2(0,0,0,2) | Details |
| 7285232 | Wassermann NH, Erlanger BF: Agents related to a potent activator of the acetylcholine receptor of Electrophorus electricus. Chem Biol Interact. 1981 Sep;36(3):251-8. The synthesis of a number of compounds related to trans-3,3'-bis [alpha-(trimethylammonium) methyl] azobenzene dibromide (trans-3,3'-BisQ) (1) is described. |
2(0,0,0,2) | Details |
| 1460456 | Chabala LD: Voltage dependence of acetylcholine receptor channel gating in rat myoballs. J Gen Physiol. 1992 Oct;100(4):729-48. Myoballs were bathed in a solution containing a low concentration of the inactive isomer of the photoisomerizable azobenzene derivative, cis-Bis-Q. |
2(0,0,0,2) | Details |
| 6604226 | Cleveland WL, Wassermann NH, Sarangarajan R, Penn AS, Erlanger BF: Monoclonal antibodies to the acetylcholine receptor by a normally functioning auto-anti-idiotypic mechanism. Nature. 1983 Sep 1-7;305(5929):56-7. Antibodies were prepared in rabbits to a structurally constrained agonist of AChR, trans-3,3'-bis [alpha-(trimethylammonio) methyl] azobenzene (BisQ). |
2(0,0,0,2) | Details |
| 2413914 | Chabala LD, Gurney AM, Lester HA: Photoactivation and dissociation of agonist molecules at the nicotinic acetylcholine receptor in voltage-clamped rat myoballs. Biophys J. 1985 Aug;48(2):241-6. The photochemical properties of the azobenzene derivative, Bis-Q, were exploited to carry out an agonist concentration jump followed by a molecular rearrangement of bound agonist molecules at receptor channels of voltage-clamped rat myoballs. |
1(0,0,0,1) | Details |
| 6835200 | Nerbonne JM, Sheridan RE, Chabala LD, Lester HA: cis-3,3'-Bis-[alpha-(trimethylammonium) methyl] azobenzene (cis-Bis-Q). Mol Pharmacol. 1983 Mar;23(2):344-9. Purification and properties at acetylcholine receptors of Electrophorus electroplaques.. |
1(0,0,0,1) | Details |
| 5288770 | Bartels E, Wassermann NH, Erlanger BF: Photochromic activators of the acetylcholine receptor. . Proc Natl Acad Sci U S A. 1971 Aug;68(8):1820-3. Trans-3,3'-bis [alpha-(trimethylammonium) methyl] azobenzene dibromide (Bis-Q), one of the most potent ever reported, is active at concentrations of less than 10 (-7) M. |
1(0,0,0,1) | Details |
| 4045419 | Krouse ME, Lester HA, Wassermann NH, Erlanger BF: Rates and equilibria for a photoisomerizable antagonist at the acetylcholine receptor of Electrophorus electroplaques. J Gen Physiol. 1985 Aug;86(2):235-56. Voltage-jump and light-flash experiments have been performed on isolated Electrophorus electroplaques exposed simultaneously to nicotinic agonists and to the photoisomerizable compound 2,2'-bis-[alpha-(trimethylammonium) methyl]-azobenzene (2BQ). |
1(0,0,0,1) | Details |
| 2422352 | Chabala LD, Gurney AM, Lester HA: Dose-response of acetylcholine receptor channels opened by a flash-activated agonist in voltage-clamped rat myoballs. J Physiol. 1986 Feb;371:407-33. To minimize problems associated with bath applied agonists, myoballs were bathed in a solution containing the inactive (cis) isomer of the photo-isomerizable azobenzene derivative, Bis-Q. |
1(0,0,0,1) | Details |
| 6308248 | Weinstock MM: Activation and desensitization of acetylcholine receptors in fish muscle with a photoisomerizable agonist. J Physiol. 1983 May;338:423-33. Voltage-clamped muscle fibres of the fish Xenomystus nigris were bathed in a solution containing 3,3-bis [alpha-(trimethylammonium) methyl] azobenzene (cis-Bis-Q; 100 nM). |
1(0,0,0,1) | Details |