Protein Information

Name H ras
Synonyms C H RAS; Transforming protein p21; N ras; HRAS1; HRASP; C H ras 1 protein N terminal fragment (37 AA); C has/bas p21 protein; C ras Ki 2 protein…

Compound Information

Name azobenzene
CAS diphenyldiazene

Reference List

PubMed Abstract RScore(About this table)
10798712 Ohnishi S, Murata M, Oikawa S, Hiraku Y, Kawanishi S: Copper-dependent DNA damage induced by hydrazobenzene, an azobenzene metabolite. Free Radic Res. 2000 Jun;32(6):469-78.

To clarify the mechanism of carcinogenesis by azobenzene and hydrazobenzene, we investigated DNA damage induced by hydrazobenzene, using 32P-5'-end-labeled DNA fragments obtained from the c-Ha-ras-1 protooncogene and the p53 tumor suppressor gene.
31(0,1,1,1) Details
1848477 Li H, Lee GH, Liu J, Nomura K, Ohtake K, Kitagawa T: Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino) azobenzene-induced rat hepatocellular carcinomas. Cancer Lett. 1991 Jan;56(1):17-24.

Only one cell line established from a AAF-treated rat liver demonstrated transforming activity with a point mutation and ATTA transversion at the second position of H-ras codon 61.
1(0,0,0,1) Details