Protein Information

Name NMDA receptor (protein family or complex)
Synonyms Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors

Compound Information

Name carbofuran
CAS

Reference List

PubMed Abstract RScore(About this table)
17188316 Gupta RC, Milatovic S, Dettbarn WD, Aschner M, Milatovic D: Neuronal oxidative injury and dendritic damage induced by carbofuran: protection by memantine. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):97-105. Epub 2006 Nov 1.

Pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist memantine (18 mg/kg, sc), in combination with atropine sulfate (16 mg/kg, sc), significantly attenuated carbofuran-induced changes in AChE activity and levels of F (2)-IsoPs and F (4)-NeuroPs, declines in HEPs, as well as the alterations in morphology of hippocampal neurons.
31(0,1,1,1) Details
16518518 Milatovic D, Gupta RC, Aschner M: Anticholinesterase toxicity and oxidative stress. ScientificWorldJournal. 2006 Feb 28;6:295-310.

Pretreatment with N-methyl D-aspartate (NMDA) receptor antagonist memantine, in combination with atropine sulfate, provides significant protection against inhibition of AChE, increases of ROS/RNS, and depletion of high-energy phosphates induced by DFP/carbofuran.
31(0,1,1,1) Details