| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | carbofuran |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15560889 | Usmani KA, Hodgson E, Rose RL: In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, and Chem Biol Interact. 2004 Dec 7;150(3):221-32. Carbofuran is metabolized by cytochrome P450 (CYP) leading to the production of one major ring oxidation metabolite, 3-hydroxycarbofuran, and two minor metabolites. |
112(1,2,2,2) | Details |
| 10563966 | Keseru GM, Balogh G, Czudor I, Karancsi T, Feher A, Bertok B: Chemical models of cytochrome P450 catalyzed insecticide metabolism. J Agric Food Chem. 1999 Feb;47(2):762-9. Cytochrome P450 (CP450) catalyzed oxidative metabolism of carbofuran (1), carbaryl (2), and pirimicarb (3) has been modeled using biomimetic oxidations catalyzed by iron (III) tetraarylporphyrins. |
82(1,1,1,2) | Details |
| 16931442 | Kaur M, Sandhir R: Comparative effects of acute and chronic carbofuran exposure on oxidative stress and drug-metabolizing enzymes in liver. Drug Chem Toxicol. 2006;29(4):415-21. Cytochrome P450 was significantly induced in liver of animals treated with acute as well as chronic carbofuran. |
6(0,0,1,1) | Details |
| 18576220 | Hernandez-Moreno D, Soler-Rodriguez F, Miguez-Santiyan MP, Perez-Lopez M: Hepatic monooxygenase (CYP1A and CYP3A) and UDPGT enzymatic activities as biomarkers for long-term carbofuran exposure in tench (Tinca tinca L). J Environ Sci Health B. 2008 Jun;43(5):395-404. Microsomal hepatic cytochrome P450 subfamily 1A (CYP1A) and 3A (CYP3A) activities, as well as the phase II enzyme diphospho-glucuronosyltransferase (UDPGT) activity were evaluated as adequate biomarkers of fish exposure to environmentally relevant concentrations of the pesticide carbofuran in freshwater ecosystems. |
6(0,0,1,1) | Details |
| 8593046 | Shao ZQ, Behki R: Characterization of the expression of the thcB gene, coding for a pesticide-degrading cytochrome P-450 in Rhodococcus strains. Appl Environ Microbiol. 1996 Feb;62(2):403-7. Atrazine, simazine, or carbofuran, although metabolized by the system, had no effect on the thcB-lacZ expression. |
3(0,0,0,3) | Details |
| 739223 | Donovan MP, Schein LG, Thomas JA: Effects of pesticides on metabolism of steroid hormone by rodent liver microsomes. J Environ Pathol Toxicol. 1978 Nov-Dec;2(2):447-54. Organochlorine and organophosphate pesticides tended to inhibit liver steroid hydroxylations, while carbofuran slightly stimulated them. All the pesticides bound to cytochrome P-450, producing Type I spectral changes. |
1(0,0,0,1) | Details |
| 20307514 | Abass K, Reponen P, Mattila S, Pelkonen O: Metabolism of carbosulfan II. Chem Biol Interact. 2010 Mar 20. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved.. The primary metabolic pathways were detoxification by the initial oxidation of to carbosulfan sulfinamide oxidation pathway') and activation via cleavage of the bond (N-S) to give carbofuran and dibutylamine ('carbofuran pathway'). |
1(0,0,0,1) | Details |
| 9592930 | Keseru GM: [Application of theoretical and synthetic models to cytochrome P450 catalysed metabolic reactions]. Acta Pharm Hung. 1998 Mar;68(2):65-9. Metabolism of an AChE inhibitor, carbofuran was studied. |
1(0,0,0,1) | Details |
| 1305879 | Kokshareva NV: [The therapeutic efficacy of alloxime in experimental pesticide poisoning]. Eksp Klin Farmakol. 1992 Nov-Dec;55(6):51-3. The new cholinesterase reactivator alloxime, 10 mg/kg, shows a marked therapeutical benefits in acute intoxication rats with carbamine pesticides such as carbofuran, pirimor, elocron. The mechanism of alloxime's therapeutical action is due to its capacity to restore cholinesterase activity in the central nervous system, normalizing neuromuscular transmission and hepatic and renal cytochrome P-450 levels. |
1(0,0,0,1) | Details |
| 7520052 | Pillai UA, Schlenk D, Frith C, Ferguson PW: Effect of bleomycin-induced fibrosis on pulmonary metabolism of selected xenobiotics. J La State Med Soc. 1994 Jun;146(6):260-7. Two model substrates, p-nitroanisole and carbofuran, were selected to evaluate the effect of bleomycin-induced fibrosis on pulmonary disposition and metabolism using the isolated perfused lung and in vitro enzyme preparations. Lower p-nitroanisole metabolism in fibrotic lungs was consistent with lower levels of cytochrome P-450 2B1/B2 measured in bleomycin-treated lungs. |
1(0,0,0,1) | Details |
| 14658504 | Wright RJ, Scharf ME, Meinke LJ, Zhou X, Siegfried BD, Chandler LD: Larval susceptibility of an insecticide-resistant western corn rootworm (Coleoptera: Chrysomelidae) population to soil insecticides: laboratory bioassays, assays of detoxification enzymes, and field performance. J Econ Entomol. 2000 Feb;93(1):7-13. Resistance ratios (LD50 Phelps County/LD50 Saunders County) for the insecticides methyl parathion, tefluthrin, carbofuran, terbufos, and chlorpyrifos were 28.0, 9.3, 8.7, 2.6 and 1.3, respectively. |
0(0,0,0,0) | Details |