Protein Information

Name anticholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name methiocarb
CAS

Reference List

PubMed Abstract RScore(About this table)
17197007 Padilla S, Marshall RS, Hunter DL, Lowit A: Time course of cholinesterase inhibition in adult rats treated acutely with carbaryl, carbofuran, formetanate, methomyl, methiocarb, oxamyl or propoxur. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):202-9. Epub 2006 Nov 15.
82(1,1,1,2) Details
4078991 Tharwat ME, Zinkl JG: Brain cholinesterase activity in starlings and Japanese quail dosed with methiocarb. J Wildl Dis. 1985 Oct;21(4):466-9.
6(0,0,1,1) Details
17504769 McDaniel KL, Padilla S, Marshall RS, Phillips PM, Podhorniak L, Qian Y, Moser VC: Comparison of acute neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat. Toxicol Sci. 2007 Aug;98(2):552-60. Epub 2007 May 15.

The chemicals tested were carbaryl, carbofuran, formetanate, methiocarb, methomyl, oxamyl, and propoxur.
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11786345 Ivanov AN, Lukachova LV, Evtugyn GA, Karyakina EE, Kiseleva SG, Budnikov HC, Orlov AV, Karpacheva GP, Karyakin AA: Polyaniline-modified cholinesterase sensor for pesticide determination. Bioelectrochemistry. 2002 Jan;55(1-2):75-7.

The detection limits found (coumaphos, 0.002, trichlorfon, 0.04, aldicarb, 0.03, methiocarb, 0.08 mg l (-1)) make it possible to detect the pollutants in the waters on the level of limited threshold levels without sample preconcentration.
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8349949 Casale GP, Vennerstrom JL, Bavari S, Wang TL: Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbaryl. Immunopharmacol Immunotoxicol. 1993 Mar-Jun;15(2-3):199-215.

The anticholinesterase (antiCHE) insecticides, a large family of pesticides used extensively throughout the world, inhibit serine hydrolases by carbamylating or phosphorylating a serine residue at the catalytic site.
The order of potency for T cell inhibition was carbaryl = dichlorvos > methiocarb > carbofuran > paraoxon > mevinphos > aldicarb = monocrotophos.
1(0,0,0,1) Details
8568832 Buronfosse T, Moroni P, Benoit E, Riviere JL: Stereoselective sulfoxidation of the pesticide methiocarb by flavin-containing monooxygenase and cytochrome P450-dependent monooxygenases of rat liver microsomes. J Biochem Toxicol. 1995 Aug;10(4):179-89.

Anticholinesterase activity of the two sulfoxide enantiomers..
1(0,0,0,1) Details