| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | methiocarb |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10826201 | Jensen SE: Mechanisms associated with methiocarb resistance in Frankliniella occidentalis (Thysanoptera: Thripidae). J Econ Entomol. 2000 Apr;93(2):464-71. Including the synergists piperonyl butoxide, a cytochrome P-450 monooxygenase inhibitor, or S,S,S-tributylphosphorotrithioate, an esterase inhibitor, in the methiocarb bioassays partially suppressed resistance in the most resistant populations. |
31(0,1,1,1) | Details |
| 8568832 | Buronfosse T, Moroni P, Benoit E, Riviere JL: Stereoselective sulfoxidation of the pesticide methiocarb by flavin-containing monooxygenase and cytochrome P450-dependent monooxygenases of rat liver microsomes. J Biochem Toxicol. 1995 Aug;10(4):179-89. |
6(0,0,1,1) | Details |
| 15547051 | Furnes B, Schlenk D: Extrahepatic metabolism of and organophosphate thioether compounds by the flavin-containing monooxygenase and cytochrome P450 systems. Drug Metab Dispos. 2005 Feb;33(2):214-8. Epub 2004 Nov 16. Stereoselective sulfoxidation of fenthion and methiocarb by human liver, kidney, and microsomes was investigated. |
2(0,0,0,2) | Details |
| 9010587 | Grothusen A, Hardt J, Brautigam L, Lang D, Bocker R: A convenient method to discriminate between cytochrome P450 enzymes and flavin-containing monooxygenases in human liver microsomes. Arch Toxicol. 1996;71(1-2):64-71. The participation of P450 and FMO in the sulfoxidation of four containing peptides, ametryne; terbutryne, prometryne and methiocarb was investigated using human liver microsomes. |
2(0,0,0,2) | Details |
| 14977868 | Usmani KA, Karoly ED, Hodgson E, Rose RL: In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily. Drug Metab Dispos. 2004 Mar;32(3):333-9. The sulfoxidation of the thioether pesticides, phorate, disulfoton, sulprofos, and methiocarb, was investigated. |
2(0,0,0,2) | Details |
| 15788727 | Vinggaard AM, Christiansen S, Laier P, Poulsen ME, Breinholt V, Jarfelt K, Jacobsen H, Dalgaard M, Nellemann C, Hass U: Perinatal exposure to the fungicide prochloraz feminizes the male rat offspring. Toxicol Sci. 2005 Jun;85(2):886-97. Epub 2005 Mar 23. In addition cytochrome P450 (CYP) 1A activities in livers were induced by prochloraz, possibly as a result of Ah receptor activation. The purpose of this study was to investigate reproductive toxic effects after exposure during gestation and lactation to prochloraz alone and a mixture of five pesticides (deltamethrin, methiocarb, prochloraz, simazine, and tribenuron-methyl). |
1(0,0,0,1) | Details |
| 3579305 | Blee E, Durst F: Hydroperoxide-dependent sulfoxidation catalyzed by soybean microsomes. . Arch Biochem Biophys. 1987 Apr;254(1):43-52. The sulfoxidation of methiocarb, an aromatic-alkyl sulfide pesticide, catalyzed by soybean microsomes was found to be strongly stimulated in the presence of cumene and hydroperoxides. Our results seem to rule out the participation of cytochrome P-450 in this oxidation, whereas the studied sulfoxidase presents some similarities to plant peroxygenase. |
1(0,0,0,1) | Details |
| 15912569 | Espinosa PJ, Contreras J, Quinto V, Gravalos C, Fernandez E, Bielza P: Metabolic mechanisms of insecticide resistance in the western flower thrips, Frankliniella occidentalis (Pergande). Pest Manag Sci. 2005 Oct;61(10):1009-15. The interactions between six insecticides (methiocarb, formetanate, acrinathrin, deltamethrin, methamidophos and endosulfan) and three potential synergists (piperonyl butoxide (PBO), S,S,S-tributyl phosphorotrithioate (DEF) and diethyl (DEM)) were studied by topical exposure in strains selected for resistance to each insecticide, and in a susceptible strain of Frankliniella occidentalis (Pergande). These studies indicate that an enhanced detoxification, mediated by cytochrome P-450 monooxygenases, is the major mechanism imparting resistance to different insecticides in F occidentalis. |
1(0,0,0,1) | Details |