| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | endosulfan |
|---|---|
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 26707 | Agarwal DK, Seth PK, Gupta PK: Effect of endosulfan on drug metabolizing enzymes and lipid peroxidation in rat. J Environ Sci Health C. 1978;13(1):49-62. There was a marked increase in the activity of aminopyrine-N-demethylase, hydroxylase, amino-transferase and spontaneous lipid peroxidation. |
1(0,0,0,1) | Details |
| 45318 | Agarwal DK, Seth PK, Gupta PK: Effect of endosulfan on drug metabolizing enzymes and lipid peroxidation in rat. J Environ Sci Health C. 1978;13(1):49-62. There was a marked increase in the activity of aminopyrine-N-demethylase, hydroxylase, amino-transferase and spontaneous lipid peroxidation. |
1(0,0,0,1) | Details |
| 6424426 | Sriram K, Misra UK: Interaction of endosulfan and dietary on rat hepatic drug metabolising enzymes. Acta Vitaminol Enzymol. 1983;5(4):213-8. Administration of (10,000 I.U./100 g body weight) daily for ten days reduced the activity of the above mentioned enzymes, when and endosulfan were given together, reduced the endosulfan induced increase of microsomal proteins and cytochrome P-450 levels, the activity of cytochrome C-reductase, aminopyrine N-demethylase and -hydroxylase. |
37(0,1,2,2) | Details |
| 7900959 | Naqvi SM, Vaishnavi C: Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals. Comp Biochem Physiol C. 1993 Jul;105(3):347-61. Endosulfan I (a metabolite) causes a significant change in and (b) Renal toxicity: inhibition of MFOs activity was noticed in rats; other effects included changes in proximal convoluted tubules and necrosis of the tubular epithelium. (c) Hepatotoxicity: chemically-induced aminopyrine N-demethylase and hydrolase were found in rat liver, and reduction in the level occurred. (d) Hematologic toxicity: endosulfan exposure resulted in a significant decrease in the level occurred. (d) Hematologic toxicity: endosulfan exposure resulted in a significant decrease in the erythrocyte glutathione reductase, hemoglobin amount, RBC number and mean corpuscular volume. 4. |
31(0,1,1,1) | Details |
| 4093546 | Tyagi SR, Sriram K, Narayan S, Misra UK: Induction of cytochrome P-450 and synthesis by endosulfan in liver of rats: effect of quality of dietary proteins. J Environ Sci Health B. 1985 Dec;20(6):651-64. Administration of endosulfan significantly increased microsomal protein, cytochrome P-450 content and the activity of aminopyrine N-demethylase. |
12(0,0,2,2) | Details |
| 16855053 | Casabar RC, Wallace AD, Hodgson E, Rose RL: Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4. Drug Metab Dispos. 2006 Oct;34(10):1779-85. Epub 2006 Jul 19. Using 16 individual human liver microsomes (HLMs), a strong correlation was observed with endosulfan formation and S-mephenytoin N-demethylase activity of CYP2B6 (r (2) = 0.79), whereas a moderate correlation with 6 beta-hydroxylase activity of CYP3A4 (r (2) = 0.54) was observed. |
6(0,0,1,1) | Details |
| 2380476 | Srikanth NS, Seth PK: Alterations in xenobiotic metabolizing enzymes in brain and liver of rats coexposed to endosulfan and malathion. J Appl Toxicol. 1990 Jun;10(3):157-60. Endosulfan was found to induce aminopyrine-n-demethylase (81%) and hydroxylase (59%) activities significantly in liver and to a lesser extent in brain. |
6(0,0,1,1) | Details |